苯丁酸氮芥结构式
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常用名 | 苯丁酸氮芥 | 英文名 | Chlorambucil |
|---|---|---|---|---|
| CAS号 | 305-03-3 | 分子量 | 304.212 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 460.1±40.0 °C at 760 mmHg | |
| 分子式 | C14H19Cl2NO2 | 熔点 | 64ºC | |
| MSDS | 中文版 美版 | 闪点 | 232.1±27.3 °C | |
| 符号 |
GHS06, GHS08 |
信号词 | Danger |
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Synthesis and DNA cleavage activity of Bis-3-chloropiperidines as alkylating agents.
ChemMedChem 9(9) , 2178-85, (2014) Nitrogen mustards are an important class of bifunctional alkylating agents routinely used in chemotherapy. They react with DNA as electrophiles through the formation of highly reactive aziridinium ion intermediates. The antibiotic 593A, with potential antitum... |
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Enhanced anti-tumor activity of the glycoengineered type II CD20 antibody obinutuzumab (GA101) in combination with chemotherapy in xenograft models of human lymphoma.
Leuk. Lymphoma 55(9) , 2151-5160, (2014) Obinutuzumab (GA101) is a novel glycoengineered type II CD20 antibody in development for non-Hodgkin lymphoma. We compared the anti-tumor activity of obinutuzumab and rituximab in preclinical studies using subcutaneous Z138 and WSU-DLCL2 xenograft mouse model... |
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A role for oleoylethanolamide in chronic lymphocytic leukemia.
Leukemia 28(7) , 1381-7, (2014) Oleoylethanolamide (OEA) is a bioactive lipid that stimulates nuclear and G protein-coupled receptors and regulates appetite and fat metabolism. It has not previously been shown to have a role in cancer. However, a mass spectrometry-based lipidomics platform ... |
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Deciphering the interactions between chlorambucil and calf thymus DNA: a multi-spectroscopic and molecular docking study.
Arch. Biochem. Biophys. 566 , 7-14, (2015) Non-covalent interactions of chlorambucil with calf thymus DNA was investigated using multi-spectroscopic techniques and molecular docking study. Binding constant calculated was found to be 1.54×10(4)M(-1) at 290K, significantly lower than various known inter... |
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Evaluation of sphingomyelin, cholester, and phosphatidylcholine-based immobilized artificial membrane liquid chromatography to predict drug penetration across the blood-brain barrier.
Anal. Bioanal. Chem 406(25) , 6179-88, (2014) Over the past decades, several in vitro methods have been tested for their ability to predict drug penetration across the blood-brain barrier. So far, in high-performance liquid chromatography, most attention has been paid to micellar liquid chromatography an... |
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Compounds from Geijera parviflora with prostaglandin E2 inhibitory activity may explain its traditional use for pain relief.
J. Ethnopharmacol. 163 , 251-5, (2015) Australian Aboriginal people used crushed leaves of Geijera parviflora Lindl. both internally and externally for pain relief, including for toothache (Cribb and Cribb, 1981). This study tested the hypothesis that this traditional use might be at least in part... |
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Validated LC-MS/MS method for the simultaneous determination of chlorambucil and its prodrug in mouse plasma and brain, and application to pharmacokinetics.
J. Pharm. Biomed. Anal. 99 , 74-8, (2014) A simple, sensitive and rapid LC-MS/MS method was developed and validated for the simultaneous determination of chlorambucil (CHL) and the prodrug of chlorambucil (CHLS) in mouse plasma and brain tissue. Detection was performed on a Diamonsil ODS chromatograp... |
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Treatment practice in the elderly patient with chronic lymphocytic leukemia-analysis of the combined SEER and Medicare database.
Ann. Hematol. 93(8) , 1335-44, (2014) The median age at diagnosis of chronic lymphocytic leukemia (CLL) is 72, but patients enrolled in randomized trials are often a decade younger. Therapy selection and outcomes in the older, comorbid population are less understood. We evaluated treatment patter... |
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Treatment outcome in children and adolescents with relapsed Hodgkin lymphoma--results of the UK HD3 relapse treatment strategy.
Br. J. Haematol. 165(4) , 534-44, (2014) The purpose of this national retrospective study was to evaluate the outcome in children with relapsed or primary refractory Hodgkin lymphoma [HL] after a primary chemotherapy alone treatment strategy. Between 2000 and 2005, 80 children with relapsed [n = 69]... |
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ID helix-loop-helix proteins as determinants of cell survival in B-cell chronic lymphocytic leukemia cells in vitro.
Mol. Cancer 14 , 30, (2015) Members of the inhibitor of DNA-binding (ID) family of helix-loop-helix proteins have been causally implicated in the pathogenesis of several types of B-cell lineage malignancy, either on the basis of mutation or by altered expression. B-cell chronic lymphocy... |