3,3′-二氯联苯胺

一般危化品
3,3′-二氯联苯胺结构式
3,3′-二氯联苯胺结构式
常用名 3,3′-二氯联苯胺 英文名 3,3'-Dichlorobenzidine
CAS号 91-94-1 分子量 253.127
密度 1.4±0.1 g/cm3 沸点 385.0±37.0 °C at 760 mmHg
分子式 C12H10Cl2N2 熔点 133ºC
MSDS 中文版 美版 闪点 186.6±26.5 °C
符号 GHS02 GHS06 GHS08 GHS09
GHS02, GHS06, GHS08, GHS09
信号词 Danger

Evidence that 4-aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species.

Environ. Mol. Mutagen. 48(5) , 404-13, (2007)

4-Aminobyphenyl (4-Ab), benzidine (Bz), and Bz congeners were evaluated for their ability to induce genotoxicity through an oxidative mechanism. The mutagenicity of these compounds was tested in the presence and absence of Aroclor 1254-induced rat S9 mix usin...

Photodechlorination of 3,3'-dichlorobenzidine in water.

Environ. Toxicol. Chem. 21(3) , 500-6, (2002)

Laboratory experiments have been conducted to elucidate the photochemical behavior of 3,3'-dichlorobenzidine (DCB) and its congeners in aquatic systems. Photodechlorination of DCB was observed in aqueous samples that were irradiated with monochromatic radiati...

Determination of dichlorobenzidine-hemoglobin adducts by GC/MS-NCI.

Int. Arch. Occup. Environ. Health 69(4) , 240-6, (1997)

A method based on gas chromatography/mass spectrometry-negative ion chemical ionization detection (GC/MS-NCI) was developed for the determination of 3,3'-dichlorobenzidine (DCB)-hemoglobin adducts. Adducts were released from hemoglobin by mild alkaline hydrol...

Sorption of benzidine and 3,3'-dichlorobenzidine to lake sediments. 1. Conceptualization and development of a multiparameter model.

Environ. Toxicol. Chem. 24(5) , 1022-8, (2005)

Aromatic amines, such as benzidine and 3,3'-dichlorobenzidine (DCB), are part of the dyes and pigments manufacturing process. The prolonged use of these carcinogenic chemicals in the past generation has introduced a significant amount of contamination to the ...

Transport behavior of 3,3'-dichlorobenzidine in a freshwater estuary.

Environ. Toxicol. Chem. 22(1) , 20-5, (2003)

Like many hydrophobic organic compounds, 3,3'-dichlorobenzidine (DCB) partitions preferentially to (sediment) particles in lake systems. As such, the behavior of DCB in these systems is substantially affected by the movement of sediments. A field investigatio...

Identification of a new mutagen, 4,4'-diamino-3,3'-dichloro-5-nitrobiphenyl, in river water flowing through an industrial area in Wakayama, Japan.

Mutat. Res. 655(1-2) , 28-35, (2008)

3,3'-Dichlorobenzidine (DCB), which has been assigned as a possible carcinogen to humans (Group 2B) by IARC, is produced as a raw material in the manufacture of polymers and dye intermediates. In our previous paper, we identified DCB as an indirect-acting mut...

Determination of hemoglobin adducts formed in rats exposed orally with 3,3'-dichlorobenzidine by GC/MS-SIM.

Toxicol. Ind. Health 18(4) , 191-9, (2002)

3,3'-dichlorobenzidine (DCB) can be metabolically N-acetylated and/or N-oxidized, and can form hemoglobin adducts. Gas chromatography/mass spectrometry-selected ion monitoring detection mode (GC/MS-SIM) could be a good analytical method to detect them. 4-Amin...

Induction of SCEs in CHL cells by dichlorobiphenyl derivative water pollutants, 2-phenylbenzotriazole (PBTA) congeners and river water concentrates.

Mutat. Res. 678(1) , 38-42, (2009)

We recently identified dichlorobiphenyl (DCB) derivatives and 2-phenylbenzotriazole (PBTA) congeners as major mutagenic constituents of the waters of the Waka River and the Yodo River system in Japan, respectively. In this study we examined sister chromatid e...

Development of a strategy for biological monitoring in a chemical plant producing 3,3'-dichlorobenzidine dihydrochloride.

J. Toxicol. Environ. Health A 75(8-10) , 551-6, (2012)

In a chemical plant in Germany producing 3,3'-dichlorobenzidine dihydrochloride for the manufacture of colorants, blood and urine samples were taken for biological monitoring. 3,3'-Dichlorobenzidine (DBZ) was analyzed in urine by thin-layer chromatography and...

Trace-level determination of benzidine and 3,3'-dichlorobenzidine in aqueous environmental samples by online solid-phase extraction and liquid chromatography with electrochemical detection.

J. Chromatogr. Sci. 39(7) , 301-7, (2001)

A simple, rapid, and reliable online methodology for the determination of benzidine and 3,3'-dichlorobenzidine (3,3'-DCB) in natural waters is proposed. The analytes are extracted and preconcentrated from aqueous samples in a small stainless steel precolumn p...