![]() 特戊酸氯甲酯结构式
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常用名 | 特戊酸氯甲酯 | 英文名 | Chloromethyl pivalate |
---|---|---|---|---|
CAS号 | 18997-19-8 | 分子量 | 150.603 | |
密度 | 1.1±0.1 g/cm3 | 沸点 | 143.0±13.0 °C at 760 mmHg | |
分子式 | C6H11ClO2 | 熔点 | <-40ºC | |
MSDS | 中文版 美版 | 闪点 | 40.0±0.0 °C | |
符号 |
![]() ![]() GHS02, GHS07 |
信号词 | Warning |
Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).
Synthesis 44(16) , doi:10.1055/s-0031-1289791, (2012) A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of an isoindoline-annulat-ed, tricyclic sultam library, utilizing a Heck-aza-Michael (HaM) strategy, is reported. This sequence involves a Heck reaction on vi-nylsulfon... |
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Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.
Antiviral Res. 19(3) , 267-73, (1992) 9-(2-Phosphonylmethoxyethyl)adenine (PMEA; 1) was acylated with chloromethyl pivalate to afford bis(pivaloyloxymethyl) PMEA (2). The ester prodrug demonstrated enhanced in vitro potency against HSV-2 greater than 150-fold higher than the parent compound. The ... |
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An efficient method for the synthesis of sulbactam pivoxil.
Il Farmaco 55(2) , 134-5, (2000) Sulbactam pivoxil, a prodrug of the beta-lactamase inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting the reaction mixture with water and isolating the product ... |
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Effects of aluminium-containing antacid on bioavailability of ofloxacin following oral administration of pivaloyloxymethyl ester of ofloxacin as prodrug.
Biol. Pharm. Bull. 16(6) , 594-9, (1993) We newly synthesized a pivaloyloxymethyl ester of ofloxacin (OFLX-PVM) as prodrug in order to avoid the chelate formation between new quinolone and metal cations such as Al3+, Mg2+, Ca2+, or Fe2+ in the gastrointestinal tract. This compound was rapidly hydrol... |
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