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特戊酸氯甲酯

特戊酸氯甲酯结构式
特戊酸氯甲酯结构式
品牌特惠专场
常用名 特戊酸氯甲酯 英文名 Chloromethyl pivalate
CAS号 18997-19-8 分子量 150.603
密度 1.1±0.1 g/cm3 沸点 143.0±13.0 °C at 760 mmHg
分子式 C6H11ClO2 熔点 <-40ºC
MSDS 中文版 美版 闪点 40.0±0.0 °C
符号 GHS02 GHS07
GHS02, GHS07
信号词 Warning

Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).

Synthesis 44(16) , doi:10.1055/s-0031-1289791, (2012)

A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of an isoindoline-annulat-ed, tricyclic sultam library, utilizing a Heck-aza-Michael (HaM) strategy, is reported. This sequence involves a Heck reaction on vi-nylsulfon...

Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.

Antiviral Res. 19(3) , 267-73, (1992)

9-(2-Phosphonylmethoxyethyl)adenine (PMEA; 1) was acylated with chloromethyl pivalate to afford bis(pivaloyloxymethyl) PMEA (2). The ester prodrug demonstrated enhanced in vitro potency against HSV-2 greater than 150-fold higher than the parent compound. The ...

An efficient method for the synthesis of sulbactam pivoxil.

Il Farmaco 55(2) , 134-5, (2000)

Sulbactam pivoxil, a prodrug of the beta-lactamase inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting the reaction mixture with water and isolating the product ...

Effects of aluminium-containing antacid on bioavailability of ofloxacin following oral administration of pivaloyloxymethyl ester of ofloxacin as prodrug.

Biol. Pharm. Bull. 16(6) , 594-9, (1993)

We newly synthesized a pivaloyloxymethyl ester of ofloxacin (OFLX-PVM) as prodrug in order to avoid the chelate formation between new quinolone and metal cations such as Al3+, Mg2+, Ca2+, or Fe2+ in the gastrointestinal tract. This compound was rapidly hydrol...