5-AIQ盐酸盐
5-AIQ盐酸盐结构式
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常用名 | 5-AIQ盐酸盐 | 英文名 | 5-amino-2H-isoquinolin-1-one,hydrochloride |
|---|---|---|---|---|
| CAS号 | 93117-07-8 | 分子量 | 196.63400 | |
| 密度 | N/A | 沸点 | 481ºC at 760 mmHg | |
| 分子式 | C9H9ClN2O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 244.7ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.
PLoS ONE 8(2) , e55883, (2013) Ets-1 is a transcription factor that regulates many genes involved in cancer progression and in tumour invasion. It is a poor prognostic marker for breast, lung, colorectal and ovary carcinomas. Here, we identified poly(ADP-ribose) polymerase-1 (PARP-1) as a ... |
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Inhibition of matrix metalloproteinase-2 by PARP inhibitors.
Biochem. Biophys. Res. Commun. 387 , 646-50, (2009) Matrix metalloproteinase-2 (MMP-2), a ubiquitously expressed zinc-dependent endopeptidase, and poly(ADP-ribosyl) polymerase (PARP), a nuclear enzyme regulating DNA repair, are activated by nitroxidative stress associated with various pathologies. As MMP-2 pla... |
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Poly(ADP-ribose)polymerase inhibition decreases angiogenesis.
Biochem. Biophys. Res. Commun. 350 , 1056-62, (2006) Inhibitors of poly(ADP-ribose)polymerase (PARP), a nuclear enzyme involved in regulating cell death and cellular responses to DNA repair, show considerable promise in the treatment of cancer both in monotherapy as well as in combination with chemotherapeutic ... |
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Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells.
Pathobiology 76 , 108-16, (2009) The current study was designed to test the hypothesis that inhibition of poly(ADP-ribose) polymerase in colorectal cancer mediates down-regulation of metastasis-related gene expression through the regulation of nuclear factor-kappaB (NF-kappaB) activity.Mouse... |