氨基吡嗪
氨基吡嗪结构式
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常用名 | 氨基吡嗪 | 英文名 | Aminopyrazine |
|---|---|---|---|---|
| CAS号 | 5049-61-6 | 分子量 | 95.10 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 250.9±20.0 °C at 760 mmHg | |
| 分子式 | C4H5N3 | 熔点 | 118-120 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 129.1±9.0 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Distribution study of atorvastatin and its metabolites in rat tissues using combined information from UHPLC/MS and MALDI-Orbitrap-MS imaging.
Anal. Bioanal. Chem 406(19) , 4601-10, (2014) The combination of ultrahigh-resolution mass spectrometry imaging (UHRMSI) and ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC/MS/MS) was used for the identification and the spatial localization of atorvastatin (AT) an... |
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In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.
Antimicrob. Agents Chemother. 57(2) , 1012-8, (2013) New drugs for the treatment of human African trypanosomiasis are urgently needed. A number of 2-aminopyrazines/2-aminopyridines were identified as promising leads following a focused screen of 5,500 compounds for Trypanosoma brucei subsp. brucei viability. De... |
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Chemistry around imidazopyrazine and ibuprofen: discovery of novel fatty acid amide hydrolase (FAAH) inhibitors.
Eur. J. Med. Chem. 45 , 3564-74, (2010) Based on the imidazo-[1,2-a]-pyrazin-3-(7H)-one scaffold, a dual action prodrug has been designed for combining antioxidant and anti-inflammatory activities, possibly unmasked upon oxidation. The construction of the target-molecule requires two building block... |
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Identification of low molecular weight carbohydrates employing new binary mixtures for matrix-assisted laser desorption/ionisation mass spectrometry.
Rapid Commun. Mass Spectrom. 22 , 2185-2194, (2008) Various energy-absorbing substances, aminopyrazine (AP), 4,4'-azodianiline (ADA), and 1-chloro-4-hydroxyisoquinoline (CHIQ), together with their binary mixtures with existing acidic MALDI matrices were subjected to matrix-assisted laser desorption/ionisation ... |
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Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality.
Bioorg. Med. Chem. 9(4) , 1037-44, (2001) A series of 5-aryl- and 3,5-bis-aryl-2-amino-1,4-pyrazine derivatives 4 and 6, and related imidazolopyrazinones 7, has been synthesized, the aryl groups of which are catechol and/or phenol substituents. These compounds, tested against human keratinocyte cells... |
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Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia.
Biochem. Pharmacol. 80 , 1507-16, (2010) Aberrant signal transduction by mutant or overexpressed protein kinases has emerged as a promising target for treatment of acute myeloid leukemia (AML). We here present a novel low molecular weight kinase inhibitor, AKN-032, targeting the FMS-like tyrosine ki... |
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Synthesis of some new anils: part 1. Reaction of 2-hydroxy-benzaldehyde and 2-hydroxynaphthaldehyde with 2-aminopyridene and 2-aminopyrazine.
Molecules 12(8) , 1796-804, (2007) New Schiff bases derived from 2-aminopyridene and 2-aminopyrazine have been synthesized. The UV-Visible spectra of the compounds have been investigated in acetonitrile and toluene. The compounds were in tautomeric equilibrium (enol-imine O- H...N, keto-amine ... |
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Mercapturic acid formation from 2-aminopyrazine in rats.
Xenobiotica 22(11) , 1239-41, (1992) 1. The compound 2-aminopyrazine was given by oral gavage to normal rats and their urine collected. 2. A mercapturic acid containing the 2-aminopyrazine moiety was isolated from this urine. This represents the first example of this type of a metabolite from a ... |