Zaldaride马来酸盐
Zaldaride马来酸盐结构式
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常用名 | Zaldaride马来酸盐 | 英文名 | CGS 9343B |
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| CAS号 | 109826-27-9 | 分子量 | 544.60 | |
| 密度 | 1.31g/cm3 | 沸点 | 778ºC at 760 mmHg | |
| 分子式 | C30H32N4O6 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 424.3ºC |
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Calcium Signaling Is Required for Erythroid Enucleation.
PLoS ONE 11 , e0146201, (2016) Although erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing this unique developmental process. Here we show that simila... |
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The calmodulin inhibitor CGS 9343B inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells.
Toxicol. Appl. Pharmacol. 285 , 207-13, (2015) We investigated the effects of the calmodulin inhibitor CGS 9343B on voltage-dependent K(+) (Kv) channels using whole-cell patch clamp technique in freshly isolated rabbit coronary arterial smooth muscle cells. CGS 9343B inhibited Kv currents in a concentrati... |
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ATP hydrolysis is critically required for function of CaV1.3 channels in cochlear inner hair cells via fueling Ca2+ clearance.
J. Neurosci. 34(20) , 6843-8, (2014) Sound encoding is mediated by Ca(2+) influx-evoked release of glutamate at the ribbon synapse of inner hair cells. Here we studied the role of ATP in this process focusing on Ca(2+) current through CaV1.3 channels and Ca(2+) homeostasis in mouse inner hair ce... |
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Effects of Ca(2+)-ionophore A23187 and calmodulin antagonists on regulatory mechanisms of glycolysis and cell viability of NIH-3T3 fibroblasts.
Mol. Genet. Metab. 67 , 334-342, (1999) We studied here, in NIH-3T3 fibroblasts, the effect of the Ca(2+)-ionophore A23187 (which is known to increase intracellular-free Ca(2+)) on the control of glycolysis and cell viability and the action of calmodulin antagonists. Time-response studies with Ca(2... |
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Calmodulin regulates the transcriptional activity of estrogen receptors. Selective inhibition of calmodulin function in subcellular compartments.
J. Biol. Chem. 278(2) , 1195-200, (2003) The steroid hormone estrogen elicits biological effects in cells by binding to and activating the estrogen receptor (ER). Estrogen binding induces a conformational change in the receptor, inducing nuclear translocation and transcriptional activation of ER. Th... |
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Insulin stimulates binding of phosphofructokinase to cytoskeleton and increases glucose 1,6-bisphosphate levels in NIH-3T3 fibroblasts, which is prevented by calmodulin antagonists.
Mol. Genet. Metab. 65(3) , 213-9, (1998) We report here a novel mechanism of insulin action in cultures of NIH-3T3 fibroblasts. Our experiments revealed that in these cells, insulin induced a rapid and transient increase in cytoskeleton-bound phosphofructokinase (EC 2.7.1.11), the rate-limiting enzy... |
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Effect of zaldaride maleate, an antidiarrheal compound, on fecal pellet output induced by hyperpropulsion in gastrointestine of rats.
Jpn. J. Pharmacol. 82(4) , 350-2, (2000) The effect of zaldaride, a calmodulin inhibitor, on fecal pellet output in rats was compared with that of loperamide, an antidiarrheal drug. 5-Hydroxytryptamine (10 mg/kg, s.c.), neostigmine (0.3 mg/kg, s.c.) and nicotine (1.0 mg/kg, s.c.) increased fecal pel... |
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Antidiarrheal effects of zaldaride maleate after oral, intravenous and subcutaneous administration to rats.
Jpn. J. Pharmacol. 81(4) , 397-400, (1999) The antidiarrheal action of zaldaride maleate (ZAL) after oral, intravenous and subcutaneous administration was examined to determine whether ZAL acts systemically or locally in the intestine of rats. Oral administration of ZAL inhibited castor oil- and 16,16... |
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Effect of zaldaride maleate, an antidiarrheal compound, on 16,16-dimethyl prostaglandin E2-induced intestinal ion secretion in rats.
Jpn. J. Pharmacol. 83(3) , 269-72, (2000) The effect of zaldaride, a calmodulin inhibitor, on 16,16-dimethyl prostaglandin E2 (dmPGE2)-induced intestinal ion secretion was investigated in rats. Zaldaride inhibited the dmPGE2-induced increase in water content in the colon, but not that in the small in... |
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Effects of zaldaride maleate, an antidiarrheal compound, on intracellular Ca2+-mediated short-circuit current response in the rat colonic mucosa.
Jpn. J. Pharmacol. 83(1) , 86-8, (2000) The effect of zaldaride maleate (ZAL) on intracellular Ca2+-mediated short-circuit current (Isc) response in rat colonic mucosa was investigated. The Isc response to acetylcholine was partially reduced by the neuronal blocker tetrodotoxin. The tetrodotoxin-se... |