4-羟基雄烯二酮醋酸酯
4-羟基雄烯二酮醋酸酯结构式
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常用名 | 4-羟基雄烯二酮醋酸酯 | 英文名 | 4-Androsten-4-ol-3,17-dione acetate |
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| CAS号 | 61630-32-8 | 分子量 | 344.44500 | |
| 密度 | 1.18g/cm3 | 沸点 | 501.2ºC at 760 mmHg | |
| 分子式 | C21H28O4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 219.2ºC |
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Aromatase inhibitors and the treatment of breast cancer.
J. Steroid Biochem. 24 , 91, (1986) Inhibition of aromatase to reduce estrogen production by peripheral and ovarian tissue could be a useful approach to treating hormone-dependent breast cancer. Several C19, 17 keto steroids have been identified as aromatase inhibitors. The most potent of these... |
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Inhibition of estrogen biosynthesis and regression of mammary tumors by aromatase inhibitors.
Adv. Exp. Med. Biol. 138 , 179-90, (1981)
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Overview of recent development of aromatase inhibitors.
Cancer Res. 42(8 Suppl) , 3312s-3314s, (1982) Since the first publication in 1973 concerning aromatase inhibitors, several effective compounds have been reported by a number of investigators. Our studies with 4-hydroxyandrostene-3,17-dione, 4-acetoxyandrostene-3,17-dione, and 1,-4,6-androstatrienedione i... |
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Effects of aromatase inhibitor 4-hydroxyandrostenedione and other compounds in the 7, 12-dimethylbenz(a)anthracene-induced breast carcinoma model.
Cancer Res. 42(8 Suppl) , 3360s-3364s, (1982) Aromatase inhibitor, 4-hydroxyandrostene-3,17-dione (4-OHA), is a highly effective treatment in rats with 7,12-dimethylbenz(a) anthracene-induced hormone-dependent mammary tumors. Over 90% of tumors regress to less than one-half of their original size, and a ... |
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Aromatase enzyme catalysis is involved in the potent inhibition of estrogen biosynthesis caused by 4-acetoxy- and 4-hydroxy-4-androstene-3, 17-dione.
Mol. Pharmacol. 21(1) , 173-80, (1982)
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Effect of 1,4,6-androstatriene-3,17-dione (ATD), 4-hydroxy-4-androstene-3,17-dione (4-OH-A) and 4-acetoxy-4-androstene-3,17-dione (4-Ac-A) on the 5 alpha-reduction of androgens in the rat prostate.
J. Steroid Biochem. 25(4) , 593-600, (1986) The present study reports the effects exerted by 1,4,6-androstatriene-3,17-dione (ATD), 4-hydroxy-4-androstene-3,17-dione (4-OH-A) and 4-acetoxy-4-androstene-3,17-dione (4-Ac-A), three steroids known to inhibit the aromatization of androgens to estrogens, on ... |
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Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo.
Steroids 38(6) , 693-702, (1981) 4-Hydroxy-4-androstene-3,17-dione (4-OHA) and 4-acetoxy-4-androstene-3,17-dione (4-AcA), in addition to being competitive inhibitors of aromatase, cause time-dependent, irreversible, loss of enzyme activity in both human placental and rat ovarian microsomes. ... |
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Effect of aromatase inhibitor on oestrogen production in rabbit blastocysts.
J. Reprod. Fertil. 66(2) , 655-62, (1982)
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Effect of an aromatase inhibitor (4-acetoxy-4-androstene-3,17-dione) on the stimulatory action of luteinizing hormone on estradiol-17 beta synthesis by rat preovulatory follicles in vitro.
Biol. Reprod. 25(2) , 290-4, (1981)
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Induction of implantation by aromatase inhibitors in ovariectomized mice.
J. Reprod. Fertil. 72(2) , 345-9, (1984) The ability of aromatase inhibitors to induce implantation in mice was tested in animals in which implantation was delayed by ovariectomy and progesterone treatment. Implantation was consistently induced by 7 mg 4-hydroxyandrostene-3,17-dione (4-OH-A), 7 X 5 ... |