1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐
1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐结构式
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常用名 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | 英文名 | 0MPTP hydrochloride |
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| CAS号 | 23007-85-4 | 分子量 | 209.715 | |
| 密度 | N/A | 沸点 | 258.6ºC at 760mmHg | |
| 分子式 | C12H16ClN | 熔点 | 254 - 257 °C | |
| MSDS | 中文版 美版 | 闪点 | 105.8ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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Effects of neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment on ovarian development of the sapphire devil, Chrysiptera cyanea.
Fish Physiol. Biochem. 41(1) , 61-71, (2015) In the neuroendocrine system controlling fish reproduction, dopamine (DA) acts as a gonadotropin inhibitory factor and plays a role in regulating gonadal development of certain species. The present study examined the effects of chemical destruction of dopamin... |
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Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice.
Sci. Rep. 5 , 12800, (2015) We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson's disease (PD) in mice. We first show that manganese ion-accu... |
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Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.
Neurobiol. Dis. 74 , 66-75, (2015) The dopamine transporter is a key protein responsible for regulating dopamine homeostasis. Its function is to transport dopamine from the extracellular space into the presynaptic neuron. Studies have suggested that accumulation of dopamine in the cytosol can ... |
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Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model.
Neurobiol. Aging 35(11) , 2603-16, (2014) Changes in cannabinoid receptor expression and concentration of endocannabinoids have been described in Parkinson's disease; however, it remains unclear whether they contribute to, or result from, the disease process. To evaluate whether targeting the endocan... |
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Ginsenoside Rg1 Ameliorates Motor Function in an Animal Model of Parkinson's Disease.
Pharmacology 96 , 25-31, (2015) Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra (SN) and diminished dopamine levels in the striatum. Accumulating evidence supported that ginsenoside Rg1, the major pharmacological... |
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Transplantation of Human Neural Stem Cells in a Parkinsonian Model Exerts Neuroprotection via Regulation of the Host Microenvironment.
Int. J. Mol. Sci. 16 , 26473-92, (2015) Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and consequent dopamine (DA) deficit, and current treatment still remains a challenge. Although neural stem cells (NSCs) have been evaluated as appealing graft sources, me... |
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The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease.
Pharmacol. Rep. 66(4) , 660-9, (2014) The aim of this study was to examine the effect of AAV2-hIL-10 (vector containing cDNA for human interleukin 10) on dopaminergic system activity (measured as DA levels and TH mRNA expression in mouse striata), and other monoamine and amino acid neurotransmitt... |
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Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo.
Proc. Natl. Acad. Sci. U. S. A. 111(27) , 9977-82, (2014) Disruption of neurotransmitter vesicle dynamics (transport, capacity, release) has been implicated in a variety of neurodegenerative and neuropsychiatric conditions. Here, we report a novel mouse model of enhanced vesicular function via bacterial artificial c... |
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Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study.
J. Med. Chem. 51 , 760-8, (2008) The active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), N-methyl-4-phenylpyridinium (MPP(+)), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease. Inhibition of mitochondrial complex I and/or the... |
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AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons.
Exp. Neurol. 211(1) , 252-8, (2008) Neural transplantation offers the potential of treating Parkinson's disease by grafting fetal dopamine neurons to depleted regions of the brain. However, clinical studies of neural grafting in Parkinson's disease have produced only modest improvements. One of... |