马来酸依那普利
马来酸依那普利结构式
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常用名 | 马来酸依那普利 | 英文名 | Enalapril maleate |
|---|---|---|---|---|
| CAS号 | 76095-16-4 | 分子量 | 492.519 | |
| 密度 | N/A | 沸点 | 0ºC | |
| 分子式 | C24H32N2O9 | 熔点 | 143-144.5ºC | |
| MSDS | 中文版 美版 | 闪点 | 0°C | |
| 符号 |
GHS08 |
信号词 | Warning |
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Physicochemical stability of captopril and enalapril extemporaneous formulations for pediatric patients.
Pharm. Dev. Technol. 20(3) , 271-8, (2015) The prevalence of hypertension among children has been increasing. Community and Hospital Pharmacists are often challenged to provide an oral liquid extemporaneous formulation for pediatric patients, because there are no appropriate dosage drugs to the specif... |
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Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling.
Br. J. Pharmacol. 171(22) , 5076-92, (2014) Previously, a systems pharmacology model was developed characterizing drug effects on the interrelationship between mean arterial pressure (MAP), cardiac output (CO) and total peripheral resistance (TPR). The present investigation aims to (i) extend the previ... |
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Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.
Clin. Pharmacol. Ther. 96(6) , 713-22, (2014) Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) are also metabolized by this enzyme. We examined the effects... |
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Mineralocorticoid receptor blockade improves coronary microvascular function in individuals with type 2 diabetes.
Diabetes 64(1) , 236-42, (2015) Reduced coronary flow reserve (CFR), an indicator of coronary microvascular dysfunction, is seen in type 2 diabetes mellitus (T2DM) and predicts cardiac mortality. Since aldosterone plays a key role in vascular injury, the aim of this study was to determine w... |
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Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model.
Hypertension 64(4) , 801-7, (2014) Most patients with essential hypertension do not exhibit substantial renal damage. Renal autoregulation by preventing glomerular transmission of systemic pressures has been postulated to mediate this resistance. Conversely, malignant nephrosclerosis (MN) has ... |
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Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals.
J. Chromatogr. A. 1345 , 139-53, (2014) An analytical method that facilitated the analysis of 11 pharmaceuticals residue (caffeine, prazosin, enalapril, carbamazepine, nifedipine, levonorgestrel, simvastatin, hydrochlorothiazide, gliclazide, diclofenac-Na, and mefenamic acid) with a single pre-trea... |
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Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
J. Appl. Toxicol. 35(2) , 152-64, (2014) Drug-induced liver injury (DILI) is a major safety concern during drug development and remains one of the main reasons for withdrawal of drugs from the market. Although it is crucial to develop methods that will detect potential hepatotoxicity of drug candida... |
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Combination of ACE inhibitor with nicorandil provides further protection in chronic kidney disease.
Am. J. Physiol. Renal Physiol. 307(12) , F1313-22, (2014) An inhibition in the renin-angiotensin system (RAS) is one of the most widely used therapies to treat chronic kidney disease. However, its effect is occasionally not sufficient and additional treatments may be required. Recently, we reported that nicorandil e... |
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The water channel aquaporin-1 contributes to renin cell recruitment during chronic stimulation of renin production.
Am. J. Physiol. Renal Physiol. 307(11) , F1215-26, (2014) Both the processing and release of secretory granules involve water movement across granule membranes. It was hypothesized that the water channel aquaporin (AQP)1 directly contributes to the recruitment of renin-positive cells in the afferent arteriole. AQP1(... |
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Myoglobin microplate assay to evaluate prevention of protein peroxidation.
J. Pharm. Biomed. Anal. 114 , 305-11, (2015) The current therapeutic strategies are based on the design of multifunctional drug candidates able to interact with various disease related targets. Drugs that have the ability to scavenge reactive oxygen species (ROS), beyond their main therapeutic action, m... |