D-氨基葡萄糖6-磷酸
D-氨基葡萄糖6-磷酸结构式
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常用名 | D-氨基葡萄糖6-磷酸 | 英文名 | D-Glucosamine 6-phosphate |
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| CAS号 | 3616-42-0 | 分子量 | 259.15 | |
| 密度 | 1.817g/cm3 | 沸点 | 599.3ºC at 760mmHg | |
| 分子式 | C6H14NO8P | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 316.2ºC |
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Studies on the Formation of Maillard and Caramelization Products from Glucosamine Incubated at 37 °C.
J. Agric. Food Chem. 63 , 6249-61, (2015) This experiment compared the in vitro degradation of glucosamine (GlcN), N-acetylglucosamine, and glucose in the presence of NH3 incubated at 37 °C in phosphate buffer from 0.5 to 12 days. The reactions were monitored with UV-vis absorption and fluorescence e... |
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Design and synthesis of novel cell wall inhibitors of Mycobacterium tuberculosis GlmM and GlmU.
Carbohydr. Res. 346(13) , 1714-20, (2011) GlmM and GlmU are key enzymes in the biosynthesis of UDP-N-acetyl-d-glucosamine (UDP-GlcNAc), an essential precursor of peptidoglycan and the rhamnose-GlcNAc linker region in the mycobacterial cell wall. These enzymes are involved in the conversion of two imp... |
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Evidence that adrenal hexose-6-phosphate dehydrogenase can effect microsomal P450 cytochrome steroidogenic enzymes.
Biochim. Biophys. Acta 1833(9) , 2039-44, (2013) The role of adrenal hexose-6-phosphate dehydrogenase in providing reducing equivalents to P450 cytochrome steroidogenic enzymes in the endoplasmic reticulum is uncertain. Hexose-6-phosphate dehydrogenase resides in the endoplasmic reticulum lumen and co-local... |
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A missense mutation in the glucosamine-6-phosphate N-acetyltransferase-encoding gene causes temperature-dependent growth defects and ectopic lignin deposition in Arabidopsis.
Plant Cell 24(8) , 3366-79, (2012) To study the regulatory mechanisms underlying lignin biosynthesis, we isolated and characterized lignescens (lig), a previously undescribed temperature-sensitive mutant of Arabidopsis thaliana that exhibits ectopic lignin deposition and growth defects under h... |
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Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme.
Biochemistry 48(15) , 3239-46, (2009) The glmS ribozyme is the first naturally occurring catalytic RNA that relies on an exogenous, nonnucleotide cofactor for reactivity. From a biochemical perspective, the glmS ribozyme derived from Bacillus anthracis is the best characterized. However, much of ... |
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Use of a coenzyme by the glmS ribozyme-riboswitch suggests primordial expansion of RNA chemistry by small molecules.
Philos. Trans. R. Soc. Lond., B, Biol. Sci. 366(1580) , 2942-8, (2011) The glmS ribozyme-riboswitch is the first known example of a naturally occurring catalytic RNA that employs a small molecule as a coenzyme. Binding of glucosamine-6-phosphate (GlcN6P) activates self-cleavage of the bacterial ribozyme, which is part of the mRN... |
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Analysis of metal ion dependence in glmS ribozyme self-cleavage and coenzyme binding.
ChemBioChem. 11(18) , 2567-71, (2010) The bacterial glmS ribozyme is mechanistically unique among both riboswitches and RNA catalysts. Its self-cleavage activity is the basis of riboswitch regulation of glucosamine-6-phosphate (GlcN6P) production, and catalysis requires GlcN6P as a coenzyme. Prev... |
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An in vitro evolved glmS ribozyme has the wild-type fold but loses coenzyme dependence.
Nat. Chem. Biol. 9(12) , 805-10, (2013) Uniquely among known ribozymes, the glmS ribozyme-riboswitch requires a small-molecule coenzyme, glucosamine-6-phosphate (GlcN6P). Although consistent with its gene-regulatory function, the use of GlcN6P is unexpected because all of the other characterized se... |
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Rapid steps in the glmS ribozyme catalytic pathway: cation and ligand requirements.
Biochemistry 50(13) , 2424-33, (2011) The glmS ribozyme is a conserved riboswitch found in numerous Gram-positive bacteria and responds to the cellular concentrations of glucosamine 6-phosphate (GlcN6P). GlcN6P binding promotes site-specific self-cleavage in the 5' UTR of the glmS mRNA, resulting... |
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Assay for glucosamine 6-phosphate using a ligand-activated ribozyme with fluorescence resonance energy transfer or CE-laser-induced fluorescence detection.
Anal. Chem. 80(21) , 8195-201, (2008) A naturally occurring aptazyme, the glmS ribozyme, is adapted to an assay for glucosamine 6-phosphate, an effector molecule for the aptazyme. In the assay, binding of analyte allosterically activates aptazyme to cleave a fluorescently labeled oligonucleotide ... |