Alpha-羟基阿普唑仑
Alpha-羟基阿普唑仑结构式
|
常用名 | Alpha-羟基阿普唑仑 | 英文名 | Alpha-Hydroxyalprazolam |
|---|---|---|---|---|
| CAS号 | 37115-43-8 | 分子量 | 324.764 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 556.1±60.0 °C at 760 mmHg | |
| 分子式 | C17H13ClN4O | 熔点 | 129-134ºC | |
| MSDS | 中文版 美版 | 闪点 | 290.1±32.9 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
|
LC-MS/MS analysis of 13 benzodiazepines and metabolites in urine, serum, plasma, and meconium.
Methods Mol. Biol. 603 , 89-105, (2010) We describe a single method for the detection and quantitation of 13 commonly prescribed benzodiazepines and metabolites: alpha-hydroxyalprazolam, alpha-hydroxyethylflurazepam, alpha-hydroxytriazolam, alprazolam, desalkylflurazepam, diazepam, lorazepam, midaz... |
|
|
Quantitation of benzodiazepines in blood and urine using gas chromatography-mass spectrometry (GC-MS).
Methods Mol. Biol. 603 , 75-87, (2010) The benzodiazepine assay utilizes gas chromatography-mass spectrometry (GC-MS) for the analysis of diazepam, nordiazepam, oxazepam, temazepam, lorazepam, alpha-hydroxyalprazolam, and alpha-hydroxytriazolam in blood and urine. A separate assay is employed for ... |
|
|
[Pharmacological studies on alprazolam, and its main metabolites, alpha-OH-alprazolam and HB compound (author's transl)].
Igaku Kenkyu. 50(7) , 495-507, (1980)
|
|
|
Influence of dosing regimen on alprazolam and metabolite serum concentrations and tolerance to sedative and psychomotor effects.
Psychopharmacology 93 , 105, (1987) The relationships between alprazolam and metabolite concentrations and CNS effects were determined in a double-blind placebo controlled four-way crossover trial in 16 normal male volunteers. Active drug treatments consisted of 4-day regimens of 4 mg alprazola... |
|
|
Urinalysis of alpha-hydroxyalprazolam, alpha-hydroxytriazolam, and other benzodiazepine compounds by GC/EIMS.
J. Anal. Toxicol. 16 , 67, (1992) This procedure was developed as an overall benzodiazepine confirmation scheme and includes the detection of the most important urinary analytes encountered by clinical toxicology laboratories in North America: alpha-hydroxyalprazolam, alpha-hydroxytriazolam, ... |
|
|
Determination of alprazolam and alpha-hydroxyalprazolam in human plasma by gas chromatography/negative-ion chemical ionization mass spectrometry.
J. Mass Spectrom. 31(9) , 1033-8, (1996) A sensitive and specific method was developed for the determination of alprazolam and its major metabolite alpha-hydroxyalprazolam in plasma. After the addition of deuterium-labeled internal standards, plasma samples were buffered to pH 9 with 1 ml of saturat... |
|
|
Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers.
Eur. J. Clin. Pharmacol. 63(2) , 173-9, (2007) The antifungal drug ketoconazole (KTZ) is known as an inhibitor of, especially, the CYP3A subfamily, which catalyzes the metabolism of a large variety of drugs. Interactions between KTZ and CYP3A substrates have been reported both in vivo and in vitro. Most o... |
|
|
Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation.
Eur. J. Clin. Pharmacol. 68(5) , 571-7, (2012) To investigate the impact of persistent inflammation in hemodialysis (HD) patients on the pharmacokinetics of alprazolam, a cytochrome P450 (CYP) 3A4 substrate, and its metabolites and the role of HD in the impact of persistent inflammation in this clinical c... |
|
|
Metabolic interaction between ethanol, high-dose alprazolam and its two main metabolites using human liver microsomes in vitro.
J. Forensic Leg. Med. 14(6) , 348-51, (2007) Alprazolam is widely used as a short-acting antidepressant and anxiolytic agent and its effect appears at very low doses while ethanol is used as a social drug worldwide. Sometimes, toxic interactions occur following combined administration of these two drugs... |
|
|
[Determination of alpha-hydroxytrizolam and alpha hydroxyaplrazolam from urine by acetylation derivatization using gas chromatography electron capture detection].
Se Pu 22(6) , 664, (2004)
|