含羞草素
含羞草素结构式
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常用名 | 含羞草素 | 英文名 | Mimosine |
|---|---|---|---|---|
| CAS号 | 500-44-7 | 分子量 | 198.18 | |
| 密度 | 1.544g/cm3 | 沸点 | 428.6ºC at 760mmHg | |
| 分子式 | C8H10N2O4 | 熔点 | 224-228 °C | |
| MSDS | 中文版 美版 | 闪点 | 213ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response.
Nucleic Acids Res. 42(18) , 11517-27, (2014) The Replication Stress Response (RSR) is a signaling network that recognizes challenges to DNA replication and coordinates diverse DNA repair and cell-cycle checkpoint pathways. Gemcitabine is a nucleoside analogue that causes cytotoxicity by inducing DNA rep... |
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Translational downregulation of HSP90 expression by iron chelators in neuroblastoma cells.
Mol. Pharmacol. 87(3) , 513-24, (2015) Iron is an essential cellular nutrient, being a critical cofactor of several proteins involved in cell growth and replication. Compared with normal cells, neoplastic cells have been shown to require a greater amount of iron, thus laying the basis for the prom... |
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The novel function of JADE1S in cytokinesis of epithelial cells.
Cell Cycle 14 , 2821-34, (2015) JADE1 belongs to a small family of PHD zinc finger proteins that interacts with histone acetyl transferase (HAT) HBO1 and is associated with chromatin. We recently reported JADE1 chromatin shuttling and phosphorylation during G2/M to G1 transition, which was ... |
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Contribution of condensed tannins and mimosine to the methane mitigation caused by feeding Leucaena leucocephala.
Arch. Anim. Nutr. 67(3) , 169-84, (2013) Leucaena (Leucaena leucocephala), a leguminous shrub promising to cope with feed scarcity in the tropics, may help in mitigating ruminal methane (CH4) emission in the tropics as well. Two experiments were conducted to evaluate the effect of Leucaena and major... |
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Transient hypoxia-inducible factor activation in rat renal ablation and reduced fibrosis with L-mimosine.
Nephrology (Carlton.) 17(1) , 58-67, (2012) Hypoxia-inducible factor (HIF) activity during the course of chronic kidney disease (CKD) development is poorly defined, and the effect of HIF activation on CKD is still controversial. The purpose of the present study was to characterize HIF expression during... |
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Preparative scale isolation, purification and derivatization of mimosine, a non-proteinogenic amino acid.
Amino Acids 43(1) , 475-82, (2012) Focusing on drug discovery non-proteinogenic amino acids have often been used as important building blocks for construction of compound libraries in the filed of combinatorial chemistry and chemical biology. Highly homogeneous L: -mimosine, α-amino-β-(3-hydox... |
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Pretreatment with intracoronary mimosine improves postischemic myocardial functional recovery.
Surgery 150(2) , 191-6, (2011) Cytoprotective growth factors such as vascular endothelial growth factor (VEGF) play important roles in myocardial protection from ischemia/reperfusion (I/R). Accumulating evidence suggests that the hypoxia-inducible factor 1 (HIF-1) pathway is a key regulato... |
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Daboia russelli venom hyaluronidase: purification, characterization and inhibition by β-3-(3-hydroxy-4-oxopyridyl) α-amino-propionic Acid.
Curr. Top. Med. Chem 11(20) , 2556-65, (2011) The present study describes the purification and characterization of a hyaluronidase (DRHyal-II) from Daboia/Vipera russelli venom and its inhibition by β-3-(3-hydroxy-4-oxopyridyl) α-amino-propionic acid, the mimosine. Gel permeation and ion exchange chromat... |
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Upregulation of hypoxia-inducible factor 1 alpha in local vein wall is associated with enhanced venous thrombus resolution.
Thromb. Res. 128(4) , 346-51, (2011) Venous thrombus resolution may be regulated by an angiogenic process that involves the surrounding vein wall. The aims of this study were to determine whether: (i) thrombosis stimulates activation of the angiogenic transcription factor, hypoxia-inducible fact... |
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Mimosine arrests the cell cycle prior to the onset of DNA replication by preventing the binding of human Ctf4/And-1 to chromatin via Hif-1α activation in HeLa cells.
Cell Cycle 11(4) , 761-6, (2012) Though the G(1) checkpoint in mammalian cells has been known for decades, the molecular targets that prevent S-phase entry remain unknown. Mimosine is a rare plant amino acid that arrests the cell cycle in the G(1) phase before entry into S phase. Here, we sh... |