4-氨基嘧啶
4-氨基嘧啶结构式
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常用名 | 4-氨基嘧啶 | 英文名 | 4-Pyrimidinamine |
|---|---|---|---|---|
| CAS号 | 591-54-8 | 分子量 | 95.103 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 240.7±13.0 °C at 760 mmHg | |
| 分子式 | C4H5N3 | 熔点 | 154-156 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 122.6±7.0 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking.
Pain 156 , 1620-36, (2015) The neurobiological mechanisms underlying chronic pain associated with cancers are not well understood. It has been hypothesized that factors specifically elevated in the tumor microenvironment sensitize adjacent nociceptive afferents. We show that parathyroi... |
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Serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus.
J. Neurosci. 35(11) , 4540-51, (2015) The dorsal cochlear nucleus (DCN) is one of the first stations within the central auditory pathway where the basic computations underlying sound localization are initiated and heightened activity in the DCN may underlie central tinnitus. The neurotransmitter ... |
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Casein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury.
J. Pharmacol. Exp. Ther. 350(2) , 301-12, (2014) Increased N-methyl-d-aspartate receptor (NMDAR) activity and phosphorylation in the spinal cord are critically involved in the synaptic plasticity and central sensitization associated with neuropathic pain. However, the mechanisms underlying increased NMDAR a... |
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Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating.
J. Comb. Chem. 7(3) , 483-9, (2005) A series of substituted aliphatic nitriles have been trimerized to their corresponding pyrimidine structures under solvent-free conditions in the presence of catalytic quantities of potassium tert-butoxide using a focused microwave reactor. Multigram quantiti... |
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Bifunctionality of the thiamin diphosphate cofactor: assignment of tautomeric/ionization states of the 4'-aminopyrimidine ring when various intermediates occupy the active sites during the catalysis of yeast pyruvate decarboxylase.
J. Am. Chem. Soc. 134(8) , 3873-85, (2012) Thiamin diphosphate (ThDP) dependent enzymes perform crucial C-C bond forming and breaking reactions in sugar and amino acid metabolism and in biosynthetic pathways via a sequence of ThDP-bound covalent intermediates. A member of this superfamily, yeast pyruv... |
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Long-lasting anticonvulsant effect of focal cooling on experimental neocortical seizures.
Epilepsia 44(12) , 1500-5, (2003) Previous clinical and experimental observations have demonstrated that cooling the brain can rapidly terminate focal seizures. We wished to determine whether cooling at regular intervals could prevent or attenuate the development of seizures in a model of foc... |
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Theoretical studies on the electronic and energetic properties of the aminopyrimidine part of thiamin diphosphate.
Biochim. Biophys. Acta 1385(2) , 245-50, (1998) Ab initio calculations on the HF-SCF 6-31g* level were performed on tautomers as well as protonated and deprotonated species of thiamin. Aspects of the proton relay function of the 4'-aminopyrimidine ring in the thiamin catalysis were studied on model systems... |
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Two structurally distinct inhibitors of glycogen synthase kinase 3 induced centromere positive micronuclei in human lymphoblastoid TK6 cells.
Mutat. Res. 643(1-2) , 29-35, (2008) Glycogen synthase kinase 3 (GSK3) is an attractive novel pharmacological target. Inhibition of GSK3 is recently regarded as one of the viable approaches to therapy for Alzheimer's disease, cancer, diabetes mellitus, osteoporosis, and bipolar mood disorder. He... |
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4-Aminopyrimidines as novel HIV-1 inhibitors.
Bioorg. Med. Chem. Lett. 17(1) , 260-5, (2007) A series of 4-aminopyrimidines (1) was identified as novel HIV inhibitors of unknown molecular target. Structural modifications were carried out to establish its SAR and identify the linking site for target identification. A number of analogs were found to po... |
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Fully automated synthesis module for preparation of S-(2-[(18)F]fluoroethyl)-L-methionine by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin.
Nucl. Med. Biol. 30(5) , 509-12, (2003) A fully automated preparation of S-(2-[(18)F]fluoroethyl)-L-methionine (FEMET), an amino acid tracer for tumor imaging with positron emission tomography, is described. [(18)F]F(-) was produced via nuclear reaction (18)O(p,n) [(18)F] at PETtrace Cyclotron. Dir... |