4-硝基咪唑
4-硝基咪唑结构式
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常用名 | 4-硝基咪唑 | 英文名 | 4-Nitroimidazole |
|---|---|---|---|---|
| CAS号 | 3034-38-6 | 分子量 | 113.075 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 404.8±18.0 °C at 760 mmHg | |
| 分子式 | C3H3N3O2 | 熔点 | 303 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 198.6±21.2 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Binding of imidazole, 1-methylimidazole and 4-nitroimidazole to yeast cytochrome c peroxidase (CcP) and the distal histidine mutant, CcP(H52L).
Biochim. Biophys. Acta 1854 , 869-81, (2015) Imidazole, 1-methylimidazole and 4-nitroimidazole bind to yeast cytochrome c peroxidase (yCcP) with apparent equilibrium dissociation constants (KD(app)) of 3.3±0.4, 0.85±0.11, and ~0.2M, respectively, at pH7. This is the weakest imidazole binding to a heme p... |
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Apolar distal pocket mutants of yeast cytochrome c peroxidase: Binding of imidazole, 1-methylimidazole and 4-nitroimidazole to the triAla, triVal, and triLeu variants.
Biochim. Biophys. Acta 1854 , 919-29, (2015) Imidazole binding to three apolar distal heme pocket mutants of yeast cytochrome c peroxidase (CcP) has been investigated between pH4 and 8. The three CcP variants have Arg-48, Trp-51, and His-52 mutated to either all alanine, CcP(triAla), all valine, CcP(tri... |
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Analysis of four 5-nitroimidazoles and their corresponding hydroxylated metabolites in egg, processed egg, and chicken meat by isotope dilution liquid chromatography tandem mass spectrometry.
J. Agric. Food Chem. 54(6) , 2018-26, (2006) An isotope dilution liquid chromatography-electrospray ionization-tandem mass spectrometry method is presented for the simultaneous analysis of several 5-nitroimidazole-based veterinary drugs, which are dimetridazole (DMZ), ronidazole (RNZ), metronidazole (MN... |
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Synthesis of some N-substituted nitroimidazole derivatives as potential antioxidant and antifungal agents.
Eur. J. Med. Chem. 44 , 645-52, (2009) Some new nitroimidazole derivatives have been synthesized by treating 4,5-dinitro- and 2-methyl-4,5-dinitroimidazoles with epoxypropane, epichlorohydrin or phenacyl bromide in alkylation reactions. The nitro group in N-substituted 4,5-dinitro- and 2-methyl-4,... |
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New synthesis and antiparasitic activity of model 5-aryl-1-methyl-4-nitroimidazoles.
Molecules 14(8) , 2758-67, (2009) A number of 5-aryl-1-methyl-4-nitroimidazoles 5a-f have been synthesized in good yields by the Suzuki coupling reaction between 5-chloro-1-methyl-4-nitroimidazole (3) and arylboronic acids 4a-f, aided by dichlorobis-(triphenylphosphine)palladium(II), K(2)CO(3... |
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Cationic nucleoside lipids derived from universal bases: A rational approach for siRNA transfection.
Bioconjug. Chem. 21(6) , 1062-9, (2010) Cationic nucleoside lipids (CNLs) derived from 5-nitroindole and 4-nitroimidazole bases were prepared from d-ribose by using a straightforward chemical synthesis. TEM experiments indicate that these amphiphilic molecules self-assemble to form supramolecular o... |
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Sequential regimens for Helicobacter pylori eradication.
Lancet 370(9592) , 1010-2, (2007)
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A new-generation 5-nitroimidazole can induce highly metronidazole-resistantGiardia lambliain vitro
Int. J. Antimicrob. Agents 36(1) , 37-42, (2010) The 5-nitroimidazole (NI) compound C17, with a side chain carrying a remote phenyl group in the 2-position of the imidazole ring, is at least 14-fold more active against the gut protozoan parasite Giardia lamblia than the 5-NI drug metronidazole (MTR), with a... |
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Lowering of 5-nitroimidazole's mutagenicity: towards optimal antiparasitic pharmacophore.
Eur. J. Med. Chem. 44(2) , 653-9, (2009) To improve the antiparasitic pharmacophore, 20 5-nitroimidazoles bearing an arylsulfonylmethyl group were prepared from commercial imidazoles. The antiparasitic activity of these molecules was assessed against Trichomonas vaginalis, the in vitro cytotoxicity ... |
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Synthesis and biological characterisation of novel dithiocarbamate containing 5-nitroimidazole (99m)Tc-complexes as potential agents for targeting hypoxia.
Bioorg. Med. Chem. Lett. 21(1) , 394-7, (2011) With the aim to develop new potential (99m)Tc-radiopharmaceuticals for imaging hypoxia based on the formation of Tc-nitrido complexes, two novel dithiocarbamate containing metronidazole derivatives (L1 and L2) have been prepared and characterised. The synthes... |