盐酸硫利达嗪
盐酸硫利达嗪结构式
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常用名 | 盐酸硫利达嗪 | 英文名 | Thioridazine hydrochloride |
|---|---|---|---|---|
| CAS号 | 130-61-0 | 分子量 | 407.035 | |
| 密度 | N/A | 沸点 | 515.7ºC at 760 mmHg | |
| 分子式 | C21H27ClN2S2 | 熔点 | 158-1600C | |
| MSDS | 中文版 美版 | 闪点 | 265.7ºC | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Chemotherapeutic efficacy of thioridazine as an adjunct drug in a murine model of latent tuberculosis.
Tuberculosis (Edinb.) 94(6) , 695-700, (2014) Thioridazine, a potent phenothiazine compound was evaluated for its chemotherapeutic efficacy against experiment model of tuberculosis. Thioridazine potentiated the activities of both isoniazid and rifampicin (>1 log CFU reduction) against the in vitro latent... |
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Experimentally validated HERG pharmacophore models as cardiotoxicity prediction tools.
J. Chem. Inf. Model. 54(10) , 2887-901, (2014) The goal of this study was to design, experimentally validate, and apply a virtual screening workflow to identify novel hERG channel blockers. The hERG channel is an important antitarget in drug development since cardiotoxic risks remain as a major cause of a... |
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The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.
Br. J. Clin. Pharmacol. 34(3) , 262-5, (1992) Inhibition of human cytochrome P4502D6 (CYP2D6)-catalysed metabolism can lead to clinically significant alterations in pharmacokinetics. Since there is evidence that the selective serotonin reuptake inhibitor (SSRI) class of antidepressant drugs might inhibit... |
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Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6.
Drug Metab. Dispos. 27 , 1078-1084, (1999) The ability of antipsychotic drugs to inhibit the catalytic activity of five cytochrome P-450 (CYP) isoforms was compared using in vitro human liver microsomal preparations to evaluate the relative potential of these drugs to inhibit drug metabolism. The appa... |
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Effects of Ca(2+)-ionophore A23187 and calmodulin antagonists on regulatory mechanisms of glycolysis and cell viability of NIH-3T3 fibroblasts.
Mol. Genet. Metab. 67 , 334-342, (1999) We studied here, in NIH-3T3 fibroblasts, the effect of the Ca(2+)-ionophore A23187 (which is known to increase intracellular-free Ca(2+)) on the control of glycolysis and cell viability and the action of calmodulin antagonists. Time-response studies with Ca(2... |
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Heat shock proteins 70 and 90 increase calcineurin activity in vitro through calmodulin-dependent and independent mechanisms.
Biochem. Biophys. Res. Commun. 260 , 619-625, (1999) We have shown that heat shock proteins (HSPs) associated with steroid receptor complexes are involved in the activation of calcineurin by aldosterone and dexamethasone. To determine whether HSPs directly interact with calcineurin, we measured the effect of HS... |
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Effect of thioridazine on antioxidant status of HEMn-DP melanocytes.
Naunyn Schmiedebergs Arch. Pharmacol. 388 , 1097-104, (2015) Thioridazine as an antipsychotic agent was extensively used to treat various psychotic disorders, e.g. schizophrenia. However, the therapy with this drug can induce serious side effects such as extrapyramidal symptoms or ocular and skin disorders, which mecha... |
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Assessments of Thioridazine as a Helper Compound to Dicloxacillin against Methicillin-Resistant Staphylococcus aureus: In Vivo Trials in a Mouse Peritonitis Model.
PLoS ONE 10 , e0135571, (2015) The rise in antimicrobial resistance is a major global concern and requires new treatment strategies. The use of helper compounds, such as thioridazine (TDZ), an antipsychotic drug, in combination with traditional antibiotics must be investigated.The aim of t... |