8-氯-1-苯基-1H-1,5-苯并二氮杂卓-2,4(3h,5h)-二酮
8-氯-1-苯基-1H-1,5-苯并二氮杂卓-2,4(3h,5h)-二酮结构式
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常用名 | 8-氯-1-苯基-1H-1,5-苯并二氮杂卓-2,4(3h,5h)-二酮 | 英文名 | N-Desmethyl Clobazam |
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| CAS号 | 22316-55-8 | 分子量 | 286.71300 | |
| 密度 | 1.363 g/cm3 | 沸点 | 601.8ºC at 760 mmHg | |
| 分子式 | C15H11ClN2O2 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 317.7ºC | |
| 符号 |
GHS02, GHS07 |
信号词 | Danger |
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Blood concentrations of clobazam and norclobazam in a lethal case involving clobazam, meprobamate and clorazepate.
Leg. Med. (Tokyo.) 12(6) , 300-4, (2010) Clobazam is a benzodiazepine with anti-anxiety and anticonvulsant properties marketed in several countries. Norclobazam, a metabolite of clobazam, has similar pharmacological activity but weaker sedative and tranquilizing effect. The two drugs were detected b... |
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Simultaneous determination of clobazam and its major metabolite in human plasma by a rapid HPLC method.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 823(2) , 167-71, (2005) A rapid and specific HPLC method has been developed and validated for simultaneous determination of clobazam, the anticonvulsant agent, and its major metabolite in human plasma. The sample preparation was a liquid-liquid extraction with tuloene yielding almos... |
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A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam.
Brain Dev. 26(8) , 530-4, (2004) N-desmethylclobazam (N-CLB), the major metabolite of clobazam (CLB), exerts a large influence on therapeutic and adverse effects of CLB. A substantial inter-individual variability has been observed in the ratios of N-CLB concentration/CLB dose and of the N-CL... |
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Analysis of clobazam and its active metabolite norclobazam in plasma and serum using HPLC/DAD.
Scand. J. Clin. Lab. Invest. 56(7) , 609-14, (1996) This report describes a simple reversed-phase high-performance liquid chromatographic (HPLC) method with automated solid-phase extraction (SPE) for analysing clobazam and norclobazam concentrations in human serum or plasma. For the HPLC analysis the samples a... |
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Eye rolling as a manifestation of clobazam toxicity in a child with epilepsy.
Dev. Med. Child Neurol. 48(7) , 612-5, (2006) A four-year-old male with symptomatic generalized epilepsy presented with ataxia, eye rolling, and episodes of back arching which were of non-epileptic origin following the introduction of clobazam at 0.75mg/kg/day. Concurrent antiepileptic medication was lam... |
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HPLC method for simultaneous determination of clobazam and N-desmethylclobazam in human serum, rat serum and rat brain homogenates.
Biomed. Chromatogr. 3(2) , 79-81, (1989) A method for simultaneous determination of clobazam (CBZ) and its active metabolite N-desmethylclobazam (DCBZ) in various biological samples by RP-HPLC with UV detection is described. The determination of both CBZ and DCBZ is performed without derivatization.... |
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Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19.
Brain Dev. 26(1) , 63-6, (2004) We describe the case of a 10-year-old girl with two epileptic seizures and subcontinuous spike-waves during sleep, who presented unusual side-effects related to clobazam (CLB) monotherapy. High plasma levels of N-desmethyl-clobazam (N-CLB), the major metaboli... |
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The metabolites N-desmethylclozapine and N-desmethylolanzapine produce cross-tolerance to the discriminative stimulus of the atypical antipsychotic clozapine in C57BL/6 mice.
Behav. Pharmacol. 22(5-6) , 458-67, (2011) It has been previously shown that cross-tolerance to the discriminative stimulus properties of clozapine can be demonstrated with the drug discrimination paradigm. This study examined the ability of N-desmethylclozapine and N-desmethylolanzapine (metabolites ... |
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Clobazam and N-desmethylclobazam serum concentrations in endstage renal failure and hemodialysis.
Ann. Pharmacother. 28(7-8) , 966-7, (1994)
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Disappointing results of increasing benzodiazepine dose after the development of anticonvulsant tolerance.
J. Neurol. Neurosurg. Psychiatr. 51(7) , 1008-9, (1988)
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