2-氯-6-(哌嗪-1-基)吡嗪盐酸盐
2-氯-6-(哌嗪-1-基)吡嗪盐酸盐结构式
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常用名 | 2-氯-6-(哌嗪-1-基)吡嗪盐酸盐 | 英文名 | MK-212 |
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| CAS号 | 61655-58-1 | 分子量 | 235.11400 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C8H12Cl2N4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS06 |
信号词 | Danger |
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Serotonin activates catecholamine neurons in the solitary tract nucleus by increasing spontaneous glutamate inputs.
J. Neurosci. 32(46) , 16530-8, (2012) Serotonin (5-HT) is a critical neurotransmitter in the control of autonomic functions. 5-HT(3) receptors participate in vagal afferent feedback to decrease food intake and regulate cardiovascular reflexes; however, the phenotype of the solitary tract nucleus ... |
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Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice.
Neuropharmacology 57(3) , 259-67, (2009) 5-HT(2C) receptor agonists have considerable therapeutic potential, however there is little in vivo data to compare the potency and selectivity of 5-HT(2C) receptor agonists. Since 5-HT(2C) receptor agonists reduce locomotor activity and food intake, changes ... |
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Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.
J. Neurophysiol. 96(5) , 2177-88, (2006) The neuromodulator serotonin has a complex set of effects on the auditory responses of neurons within the inferior colliculus (IC), a midbrain auditory nucleus that integrates a wide range of inputs from auditory and nonauditory sources. To determine whether ... |
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Chronic treatment with a serotonin(2) receptor (5-HT(2)R) agonist modulates the behavioral and cellular response to (+)-3,4-methylenedioxymethamphetamine [(+)-MDMA].
Drug Alcohol Depend. 81(2) , 117-27, (2006) 3,4-Methylenedioxymethamphetamine [MDMA; ecstasy] evokes a multifaceted subjective experience in human users which includes stimulation, feelings of well-being, mood elevation, empathy towards others as well as distortions in time, sensation and perception. A... |
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Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury.
Eur. J. Pharmacol. 567(1-2) , 89-94, (2007) Intrathecal administration of serotonin type 2C (5-HT(2C)) receptor agonists produces an antiallodynic effect in a rat model of neuropathic pain. In the present study, we characterized this effect pharmacologically. Allodynia was produced by tight ligation of... |
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5-HT(2A) receptor blockade and 5-HT(2C) receptor activation interact to reduce cocaine hyperlocomotion and Fos protein expression in the caudate-putamen.
Synapse 66(12) , 989-1001, (2012) Both the 5-HT(2A) receptor (R) antagonist M100907 and the 5-HT(2C) R agonist MK212 attenuate cocaine-induced dopamine release and hyperlocomotion. This study examined whether these drugs interact to reduce cocaine hyperlocomotion and Fos expression in the str... |
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Discriminative stimulus effects of serotonin agonists, neutral antagonists, and inverse agonists in pigeons: perspectives on intrinsic efficacy measurements in vivo.
Psychopharmacology 211(2) , 149-59, (2010) The extended ternary complex theory of receptor function states a ligand can be classified as an inverse agonist, agonist, or neutral antagonist based on its ability to preferentially stabilize the inactive conformation, the active conformation, or to have no... |
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Novel approach to data analysis in cocaine-conditioned place preference.
Behav. Pharmacol. 20(8) , 720-30, (2009) Only a subgroup of human drug users progress from initial drug taking to drug addiction. The learned associations between the effects of the drug and the environment in which it is experienced is an important aspect of the progression to continued drug taking... |
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Spontaneous rhythmogenic capabilities of sympathetic neuronal assemblies in the rat spinal cord slice.
Neuroscience 170(3) , 827-38, (2010) Neuronal networks generating rhythmic activity as an emergent property are common throughout the nervous system. Some are responsible for rhythmic behaviours, as is the case for the spinal cord locomotor networks; however, for others the function is more subt... |
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Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice.
Bull. Exp. Biol. Med. 142(5) , 594-7, (2006) A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. In low dos... |