1-萘基异氰酸酯
1-萘基异氰酸酯结构式
|
常用名 | 1-萘基异氰酸酯 | 英文名 | 1-Naphthylisocyanate |
|---|---|---|---|---|
| CAS号 | 86-84-0 | 分子量 | 169.179 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 270.0±0.0 °C at 760 mmHg | |
| 分子式 | C11H7NO | 熔点 | 4-7 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 98.2±21.3 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
|
Measurement of plasma free choline by high performance liquid chromatography with fluorescence detection following derivatization with 1-naphthyl isocyanate.
Anal. Chim. Acta 644(1-2) , 90-4, (2009) Choline is an essential nutrient which is difficult to measure because it has no native absorbance or fluorescence and only relatively unreactive functional groups. The method described here uses the reaction of the hydroxyl group on choline with 1-naphthyl i... |
|
|
[Application of Pirkle-type chiral column to the resolution of enantiomeric drugs: resolution and identification of alpha-naphthyl isocyanate derivatives of alprenolol and some other beta-blockers].
Yao Xue Xue Bao 24(4) , 285-9, (1989) alpha-Naphthyl isocyanate (NI) as a derivatizing agent to separate several beta-blockers was described. This procedure is simple, rapid and gives good resolution. Experiments with NI derivatives of alprenolol showed that the isocyanate group reacted with the ... |
|
|
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.
J. Clin. Invest. 112(11) , 1678-87, (2003) Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activatio... |
|
|
Role of neutrophils in the pathogenesis of acute inflammatory liver injury.
Toxicol. Pathol. 35(6) , 757-66, (2007) Polymorphonuclear leukocytes (neutrophils) are essential in the defense against invading microorganisms, tissue trauma or any inciting inflammatory signals. Hepatic infiltration of neutrophils is an acute response to recent or ongoing liver injury, hepatic st... |
|
|
Protective effect of glycyrrhizin, glycyrrhetic acid and matrine on acute cholestasis induced by alpha-naphthyl isothiocyanate in rats.
Planta Med. 73(2) , 128-33, (2007) Alpha-naphthyl isothiocyanate (ANIT) is a known hepatotoxicant that causes acute cholestatic hepatitis characterized by the infiltration of neutrophils around bile ducts and necrotic hepatocytes. The effects of glycyrrhizin (GL), 18beta-glycyrrhetinic acid (G... |
|
|
Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats.
Toxicology 230(2-3) , 145-50, (2007) A pharmacokinetic study was carried out in rats to investigate the effects of experimental hepatic injury on the liver glucuronidation and bile excretion of ketoprofen (KP) and its glucuronides (KPGs). In vivo, KP (20mg/kg b.w.) was intravenously administered... |
|
|
Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation.
World J. Gastroenterol. 11(27) , 4167-72, (2005) To build up the research models of hepatic fibrosis in mice.Inbred wild-type FVB/N mice were either treated with alpha-naphthyl-isothiocyanate (ANIT), allyl alcohol (AA), carbon tetrachloride (CCl(4)), 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), and sili... |
|
|
Enantioselective high-performance liquid chromatography of therapeutically relevant aminoalcohols as their fluorescent 1-naphthyl isocyanate derivatives.
Biomed. Chromatogr. 15(3) , 212-6, (2001) A method for determining the enantiomers of 10 therapeutically relevant aminoalcohols using HPLC and precolumn derivatization was developed. Naphthyl isocyanate reacted with racemic aminoalcohols to form urea derivatives which were separated isocratically on ... |