胞苷-3',5'-环一磷酸钠盐
胞苷-3',5'-环一磷酸钠盐结构式
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常用名 | 胞苷-3',5'-环一磷酸钠盐 | 英文名 | ccmp sodium salt |
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| CAS号 | 54925-33-6 | 分子量 | 327.16300 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C9H11N3NaO7P | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone.
Exp. Dermatol. 19(5) , 470-2, (2010) Human sebaceous gland possesses all the steroidogenic enzymes required for androgen synthesis. It remains unclear whether the testosterone produced in situ mainly derives from circulating dehydroepiandrosterone (DHEA) or from de novo synthesis utilizing serum... |
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Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling
Toxicol. Lett. 184(3) , 169-75, (2009) Testicular Leydig cells express estrogen receptors and are the predominant source of the male sex steroid hormone testosterone (T). Previous studies demonstrated that genistein acts through estrogen receptors in Leydig cells. In the present study, pre-treatme... |
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Regulation of the system x(C)- cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures.
Glia 59(10) , 1387-401, (2011) The system x(C)- (Sx(C)-) transporter functions to mediate the exchange of extracellular cystine (L-Cys(2)) and intracellular glutamate (L-Glu). Internalized L-Cys(2) serves as a rate-limiting precursor for the biosynthesis of glutathione (GSH), while the ext... |
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Cyclic cytidine 3',5'-monophosphate (cCMP) signals via cGMP kinase I.
FEBS Lett. 584(18) , 3979-84, (2010) We analysed the function and intracellular signalling of the cyclic pyrimidinic nucleotide cCMP. The membrane-permeable cCMP analogue dibutyryl-cCMP mediated mouse aorta relaxation. cCMP activated purified cGMP-dependent protein kinase (cGK) Iα and Iβ and sti... |
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Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport.
Am. J. Physiol. Gastrointest. Liver Physiol. 296(1) , G93-100, (2009) Aquaporin-8 (AQP8) water channels, which are expressed in rat hepatocyte bile canalicular membranes, are involved in water transport during bile formation. Nevertheless, there is no conclusive evidence that AQP8 mediates water secretion into the bile canalicu... |
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Identification of the Raf-1 signaling pathway used by cAMP to inhibit p42/p44 MAPK in rat lacrimal gland acini: role in potentiation of protein secretion.
Invest. Ophthalmol. Vis. Sci. 51(12) , 6321-8, (2010) The lacrimal gland is primarily responsible for the aqueous portion of the tear film. Simultaneous addition of cholinergic agonists or growth factors with cAMP-dependent agonists potentiates secretion. Recent investigations revealed that cAMP decreases p44/p4... |
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Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway.
J. Endocrinol. 198(1) , 193-207, (2008) Previous studies from this laboratory identified excessive oxidative stress as an important mediator of age-related decline in steroid hormone production. Here, we investigated whether oxidative stress exerts its antisteroidogenic action through modulation of... |
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Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP.
Cell Death Dis. 3 , e326, (2012) Neurofibrillary tangles (NFTs) are hallmarks of Alzheimer's disease (AD). The main component of NFTs is TAU, a highly soluble microtubule-associated protein. However, when TAU is cleaved at Asp421 by caspases it becomes prone to aggregation leading to NFTs. W... |
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Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP.
Am. J. Physiol. Heart Circ. Physiol. 296(3) , H728-34, (2009) Downregulation of the sarcoplasmic reticulum calcium ATPase (SERCA2) is associated with diastolic dysfunction in the failing heart. Elevated plasma endothelin-1 (ET) levels are correlated with congestive heart failure suggesting that ET may play a pathophysio... |
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Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light.
J. Neurochem. 107(5) , 1314-24, (2008) The retina-specific G protein-coupled receptor kinases, GRK1 and GRK7, have been implicated in the shutoff of the photoresponse and adaptation to changing light conditions via rod and cone opsin phosphorylation. Recently, we have defined sites of phosphorylat... |