辣椒平
辣椒平结构式
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常用名 | 辣椒平 | 英文名 | Capsazepine |
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| CAS号 | 138977-28-3 | 分子量 | 376.900 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 581.1±60.0 °C at 760 mmHg | |
| 分子式 | C19H21ClN2O2S | 熔点 | 155-157°C | |
| MSDS | 中文版 美版 | 闪点 | 305.3±32.9 °C |
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Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation.
BMC Cancer 14 , 921, (2014) There is evidence that calcium (Ca(2+)) increases the proliferation of human advanced prostate cancer (PCa) cells but the ion channels involved are not fully understood. Here, we investigated the correlation between alpha(1D)-adrenergic receptor (alpha(1D)-AR... |
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Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1.
Biochem. Pharmacol. 92(2) , 312-25, (2014) Cannabinoids have been shown to promote the expression of the intercellular adhesion molecule 1 (ICAM-1) on lung cancer cells as part of their anti-invasive and antimetastatic action. Using lung cancer cell lines (A549, H460) and metastatic cells derived from... |
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Piperine inhibits the growth and motility of triple-negative breast cancer cells.
Cancer Lett. 357(1) , 129-40, (2014) Piperine, an alkaloid from black pepper, is reported to have anticancer activities. In this study, we investigated the effect of piperine on the growth and motility of triple-negative breast cancer (TNBC) cells. Piperine inhibited the in vitro growth of TNBC ... |
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Activation of PPAR gamma receptors reduces levodopa-induced dyskinesias in 6-OHDA-lesioned rats.
Neurobiol. Dis. 74 , 295-304, (2015) Long-term administration of l-3,4-dihydroxyphenylalanine (levodopa), the mainstay treatment for Parkinson's disease (PD), is accompanied by fluctuations in its duration of action and motor complications (dyskinesia) that dramatically affect the quality of lif... |
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Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.
Carcinogenesis 35(12) , 2787-97, (2014) Cannabigerol (CBG) is a safe non-psychotropic Cannabis-derived cannabinoid (CB), which interacts with specific targets involved in carcinogenesis. Specifically, CBG potently blocks transient receptor potential (TRP) M8 (TRPM8), activates TRPA1, TRPV1 and TRPV... |
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Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa.
PLoS ONE 10 , e0127060, (2015) Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways. Previously, we identified ... |
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Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms.
J. Neurosci. 35 , 8593-603, (2015) Nerve growth factor (NGF) is elevated in certain chronic pain conditions and is a sufficient stimulus to cause lasting pain in humans, but the actual mechanisms underlying the persistent effects of NGF remain incompletely understood. We developed a rat model ... |
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Ethanol attenuation of long-term depression in the nucleus accumbens can be overcome by activation of TRPV1 receptors.
Alcohol. Clin. Exp. Res. 38(11) , 2763-9, (2014) Altered expression of synaptic plasticity within the nucleus accumbens (NAc) constitutes a critical neuroadaptive response to ethanol (EtOH) and other drugs of abuse. We have previously reported that N-methyl-D-aspartate receptor (NMDAR)-dependent long-term d... |
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ZO-1 and -2 Are Required for TRPV1-Modulated Paracellular Permeability.
J. Dent. Res. 94 , 1748-56, (2015) The tight junction-based paracellular pathway plays an important role in saliva secretion. Zonula occludens (ZO) proteins are submembranous proteins of tight junction complex; however, their function in salivary epithelium is poorly understood. Here, we found... |
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Intracolonic Administration of the TRPA1 Agonist Allyl Isothiocyanate Stimulates Colonic Motility and Defecation in Conscious Dogs.
J. Gastrointest. Surg. 19 , 1342-9, (2015) The aim of the present study was to investigate the effects of the intracolonic transient receptor potential (TRP) A1 agonist allyl isothiocyanate (AITC) on colonic motility and defecation.The effects of AITC administered into the proximal colonic lumen on co... |