3-氨基-7-甲基氨基吩噻嗪-5-氯化物
3-氨基-7-甲基氨基吩噻嗪-5-氯化物结构式
|
常用名 | 3-氨基-7-甲基氨基吩噻嗪-5-氯化物 | 英文名 | 3-Amino-7-(methylamino)phenothiazin-5-ium chloride |
|---|---|---|---|---|
| CAS号 | 531-57-7 | 分子量 | 277.77 | |
| 密度 | N/A | 沸点 | 385.1ºC at 760 mmHg | |
| 分子式 | C13H12ClN3S | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 186.7ºC |
|
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009) Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligomers and linear fibrils, which possess distinct biological ac... |
|
|
Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
J. Biol. Chem. 282 , 10311-24, (2007) Alzheimer disease is characterized by the abnormal aggregation of amyloid beta peptide into extracellular fibrillar deposits known as amyloid plaques. Soluble oligomers have been observed at early time points preceding fibril formation, and these oligomers ha... |
|
|
Note from the Biological Stain Commission: revision of azure B assay protocol.
Stain Technol. 63(1) , 65-9, (1988)
|
|
|
Electrochemical sensing based on redox mediation at carbon nanotubes.
Anal. Chem. 77(13) , 3960-5, (2005) An electrochemical sensing platform was developed based on the integration of redox mediators and carbon nanotubes (CNT) in a polymeric matrix. To demonstrate the concept, a redox mediator Azure dye (AZU) was covalently attached to polysaccharide chains of ch... |
|
|
Chemical manipulation of hsp70 ATPase activity regulates tau stability.
J. Neurosci. 39th ed., 30;29 , 12079-12088, (2009) Alzheimer's disease and other tauopathies have recently been clustered with a group of nervous system disorders termed protein misfolding diseases. The common element established between these disorders is their requirement for processing by the chaperone com... |
|
|
Application of Azure C for the extractive spectrophotometric determination of microgram amounts of penicillin.
J. Pharmacol. Methods 13(3) , 275-80, (1985) A simple, accurate, and rapid method for the quantitative determination of penicillin is proposed. The method is based on the formation of a blue penicillin-Azure-C ion-pair that can be extracted into chloroform in phosphate-citric acid buffer. The molar abso... |
|
|
Interference of low-molecular substances with the thioflavin-T fluorescence assay of amyloid fibrils.
J. Pept. Sci. 18(1) , 59-64, (2012) Abnormal fibrillization of amyloidogenic peptides/proteins has been linked to various neurodegenerative diseases such as Alzheimer's and Parkinson's disease as well as with type-II diabetes mellitus. The kinetics of protein fibrillization is commonly studied ... |
|
|
Targeted neuronal lesion induced by photosensitizing dyes.
Brain Res. 534(1-2) , 122-8, (1990) Free radical-induced phototoxicity mediated by laser irradiation was investigated in the rabbit facial nerve. Azure-C, mesoporphyrin, or the dye conjugated to the protein carrier horseradish peroxidase were injected into the levator alae nasi muscle. Two to 7... |