17α-雌二醇
17α-雌二醇结构式
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常用名 | 17α-雌二醇 | 英文名 | 17alpha-Estradiol |
|---|---|---|---|---|
| CAS号 | 57-91-0 | 分子量 | 272.382 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 445.9±45.0 °C at 760 mmHg | |
| 分子式 | C18H24O2 | 熔点 | 176-180ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 209.6±23.3 °C | |
| 符号 |
GHS08 |
信号词 | Warning |
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Virtual and biomolecular screening converge on a selective agonist for GPR30.
Nat. Chem. Biol. 2 , 207-12, (2006) Estrogen is a hormone critical in the development, normal physiology and pathophysiology of numerous human tissues. The effects of estrogen have traditionally been solely ascribed to estrogen receptor alpha (ERalpha) and more recently ERbeta, members of the s... |
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Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
J. Med. Chem. 52 , 7488-502, (2009) 17beta-Hydroxysteroid dehydrogenase type 7 (17beta-HSD7) catalyzes the reduction of estrone (E(1)) into estradiol (E(2)) and of dihydrotestosterone (DHT) into 5alpha-androstane-3beta,17beta-diol (3beta-diol), therefore modulating the level of mitogenic estrog... |
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The effect of steroids on the in vitro migration of washed human spermatozoa in modified Tyrode's solution or in fasting human blood serum.
Fertil. Steril. 32(5) , 566-70, (1979) In modified Tyrode's solution, 17 beta-estradiol at concentrations between 0.1 microgram/ml and 320 nmoles/ml was effective in increasing human spermatozoal forward migration. 17 alpha-Estradiol, although structurally similar to 17 beta-estradiol, had no effe... |
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3-Hydroxyglutarate excretion is increased in ketotic patients: implications for glutaryl-CoA dehydrogenase deficiency testing.
J. Inherit. Metab. Dis. 25(2) , 83-8, (2002) Three patients with ketosis had increased excretion of 3-hydroxyglutarate (21.8-37.9 micromol/mmol creatinine; controls 2.3 +/- 1.6), an indicator of glutaryl-CoA dehydrogenase deficiency (GDHD), which normalized when the patients were nonketotic. Clinical as... |