促进剂TETD
促进剂TETD结构式
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常用名 | 促进剂TETD | 英文名 | Disulfiram |
|---|---|---|---|---|
| CAS号 | 97-77-8 | 分子量 | 296.539 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 369.0±25.0 °C at 760 mmHg | |
| 分子式 | C10H20N2S4 | 熔点 | 69-71 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 177.0±23.2 °C | |
| 符号 |
GHS07, GHS08, GHS09 |
信号词 | Warning |
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An orphan esterase ABHD10 modulates probenecid acyl glucuronidation in human liver.
Drug Metab. Dispos. 42(12) , 2109-16, (2014) Probenecid, a widely used uricosuric agent, is mainly metabolized to probenecid acyl glucuronide (PRAG), which is considered a causal substance of severe allergic or anaphylactoid reactions. PRAG can be hydrolyzed (deglucuronidated) to probenecid. The purpose... |
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Magnetic high throughput screening system for the development of nano-sized molecularly imprinted polymers for controlled delivery of curcumin.
Analyst 140(9) , 3113-20, (2015) Curcumin is a versatile anti-inflammatory and anti-cancer agent known for its low bioavailability, which could be improved by developing materials capable of binding and releasing drug in a controlled fashion. The present study describes the preparation of ma... |
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Metabolic characterization of meso-dihydroguaiaretic acid in liver microsomes and in mice.
Food Chem. Toxicol. 76 , 94-102, (2015) meso-Dihydroguaiaretic acid (MDGA) is a major component of Myristica fragrans and Machilus thunbergii that is traditionally used as a spice and for medicinal purposes. Despite reports of various biological activities exerted by MDGA, there is no information r... |
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Fennel and raspberry leaf as possible inhibitors of acetaminophen oxidation.
Phytother Res. 28(10) , 1573-6, (2014) In addition to CYP2E1, several CYP isoenzymes, notably CYP1A2, 2D6, and 3A4, are suggested to contribute in acetaminophen oxidation and formation of the hepatotoxic metabolite N-acetyl-p-benzoquinone imine (NAPQI). The in vitro CYP2E1 inhibitory potentials of... |
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Disulfiram modulates stemness and metabolism of brain tumor initiating cells in atypical teratoid/rhabdoid tumors.
Neuro. Oncol. 17 , 810-21, (2015) Atypical teratoid/rhabdoid tumors (AT/RT) are among the most malignant pediatric brain tumors. Cells from brain tumors with high aldehyde dehydrogenase (ALDH) activity have a number of characteristics that are similar to brain tumor initiating cells (BTICs). ... |
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Effects of pharmacologic dopamine β-hydroxylase inhibition on cocaine-induced reinstatement and dopamine neurochemistry in squirrel monkeys.
J. Pharmacol. Exp. Ther. 350(1) , 144-52, (2014) Disulfiram has shown promise as a pharmacotherapy for cocaine dependence in clinical settings, although it has many targets, and the behavioral and molecular mechanisms underlying its efficacy are unclear. One of many biochemical actions of disulfiram is inhi... |
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Disulfiram-loaded immediate and extended release vaginal tablets for the localised treatment of cervical cancer.
J. Pharm. Pharmacol. 67(2) , 189-98, (2015) To develop and manufacture both immediate and sustained release vaginal tablets containing the anticancer drug disulfiram, which has the potential to be used as a non-invasive treatment for cervical cancer.Disulfiram-loaded vaginal tablets were manufactured a... |
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An Atomic Force Microscope Study Revealed Two Mechanisms in the Effect of Anticancer Drugs on Rate-Dependent Young's Modulus of Human Prostate Cancer Cells.
PLoS ONE 10 , e0126107, (2015) Mechanical properties of cells have been recognized as a biomarker for cellular cytoskeletal organization. As chemical treatments lead to cell cytoskeletal rearrangements, thereby, modifications of cellular mechanical properties, investigating cellular mechan... |
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Effects of cytochrome P450 inhibitors on peroxidase activity.
Neuro Endocrinol. Lett. 33 Suppl 3 , 33-40, (2012) Of several enzymes metabolizing xenobiotics, cytochrome P450 (CYP) and peroxidase enzymes seem to be most important. One of the major challenges in studies investigating metabolism of xenobiotics is to resolve which of these two groups of enzymes is predomina... |
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Cytochrome p450-mediated metabolic activation of diosbulbin B.
Drug Metab. Dispos. 42(10) , 1727-36, (2014) Diosbulbin B (DIOB), a furan-containing diterpenoid lactone, is the most abundant component of Dioscorea bulbifera L. (DB), a traditional Chinese medicine herb. Administration of purified DIOB or DB extracts has been reported to cause liver injury in animals.... |