木香烃内酯
木香烃内酯结构式
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常用名 | 木香烃内酯 | 英文名 | Costunolide |
|---|---|---|---|---|
| CAS号 | 553-21-9 | 分子量 | 232.318 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 385.4±42.0 °C at 760 mmHg | |
| 分子式 | C15H20O2 | 熔点 | 106 °C | |
| MSDS | 中文版 美版 | 闪点 | 162.0±25.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang.
J. Ethnopharmacol. 156 , 182-9, (2014) Guibi-tang (Guipi-tang in Chinese and Kihi-to in Japanese) is a multi-herb traditional medicine commonly prescribed to treat psychoneurosis in East Asia. Although this medicine has been widely used, there is little available information on the safety and toxi... |
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Simultaneous quantification of curdione, furanodiene and germacrone in rabbit plasma using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.
Biomed. Chromatogr. 29 , 1393-8, (2015) A simple, rapid and sensitive method was developed for the simultaneous quantification of curdione, furanodiene and germacrone in rabbit plasma using a LC-MS/MS analysis. The plasma sample preparation was a simple deproteinization by the addition of 3 vols of... |
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A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers.
Toxicol. Appl. Pharmacol. 289 , 177-84, (2015) Skin sensitization is an important toxicological end-point in the risk assessment of chemical allergens. Because of the complexity of the biological mechanisms associated with skin sensitization, integrated approaches combining different chemical, biological ... |
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Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne.
Mol. Med. Report. 12 , 7789-95, (2015) Aucklandia lappa Decne, a well-known traditional herbal medicine, is used for the treatment of asthma, rheumatism, coughs, tuberculosis and numerous other diseases. The present study evaluated the inhibitory effects of the three sesquiterpene lactones costuno... |
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Heliolactone, a non-sesquiterpene lactone germination stimulant for root parasitic weeds from sunflower.
Phytochemistry 108 , 122-8, (2014) Root exudates of sunflower (Helianthus annuus L.) line 2607A induced germination of seeds of root parasitic weeds Striga hermonthica, Orobanche cumana, Orobanche minor, Orobanche crenata, and Phelipanche aegyptiaca. Bioassay-guided purification led to the iso... |
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Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells.
Radiat. Oncol. 6 , 56, (2011) This work aimed to investigate the effect of costunolide, a sesquiterpene lactone isolated from Michelia compressa, on cell cycle distribution and radiosensitivity of human hepatocellular carcinoma (HCC) cells.The assessment used in this study included: cell ... |
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Quantitative analysis of costunolide and dehydrocostuslactone in rat plasma by ultraperformance liquid chromatography-electrospray ionization-mass spectrometry.
Biomed. Chromatogr. 25(5) , 547-54, (2011) Costunolide and dehydrocostuslactone are well-known sesquiterpene lactones contained in many plants used as popular herbs, such as Saussurea lappa and Laurus novocanariensis, and have been considered as potential candidates for the treatment of various types ... |
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Effects of a hexane extract from Laurus novocanariensis leaves on the ethanol metabolism of Wistar rats.
Fitoterapia 80(2) , 130-3, (2009) A hexane extract from the leaves of Laurus novocanariensis was investigated for its activity on ethanol metabolism in Wistar rats. The extract could interfere with blood ethanol elevation, the induction of gastric alcohol dehydrogenase (ADH) and the reduction... |
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Costunolide inhibits osteoclast differentiation by suppressing c-Fos transcriptional activity.
Phytother Res. 28(4) , 586-92, (2014) Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis. However, its effects and mechanism of action in osteoclasts remain unknown. Herein, we found that costunolide significantly inhibited RANKL-in... |
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Regulatory effects of costunolide on dopamine metabolism-associated genes inhibit dopamine-induced apoptosis in human dopaminergic SH-SY5Y cells.
Neurosci. Lett. 507(2) , 101-5, (2012) Parkinson's disease (PD) is characterized by the selective loss of dopaminergic (DAergic) neurons in the substantia nigra and the subsequent depletion of dopamine (DA). This study assessed the protective effects of costunolide on DA-induced apoptosis in human... |