异补骨脂素
异补骨脂素结构式
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常用名 | 异补骨脂素 | 英文名 | Angelicin |
|---|---|---|---|---|
| CAS号 | 523-50-2 | 分子量 | 186.163 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 362.6±27.0 °C at 760 mmHg | |
| 分子式 | C11H6O3 | 熔点 | 132-134ºC | |
| MSDS | 中文版 美版 | 闪点 | 173.1±23.7 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Warning |
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Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography.
Food Chem. 186 , 133-8, (2015) An efficient strategy, based on bioassay-guided fractionation, high-performance liquid chromatography (HPLC), and high-performance counter-current chromatography (HPCCC), was established to purify and evaluate the bioactive compounds from the dichloromethane ... |
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Application of the equivalency factor concept to the phototoxicity and –genotoxicity of furocoumarin mixtures
Food Chem. Toxicol. 68 , 257-66, (2014) • The photo-cytotoxic, -mutagenic, and -clastogenic properties in V79 cells of thirteen furocoumarins (FCs), were analyzed. • Nine FC mixtures including one mixture ‘representing’ FCs in Angelica archangelica extract were tested. • The concept of relative pot... |
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F420H2-dependent degradation of aflatoxin and other furanocoumarins is widespread throughout the actinomycetales.
PLoS ONE 7(2) , e30114, (2012) Two classes of F(420)-dependent reductases (FDR-A and FDR-B) that can reduce aflatoxins and thereby degrade them have previously been isolated from Mycobacterium smegmatis. One class, the FDR-A enzymes, has up to 100 times more activity than the other. F(420)... |
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Differentiation and apoptosis in UVA-irradiated cells treated with furocoumarin derivatives.
Ann. N. Y. Acad. Sci. 1171 , 334-44, (2009) In this review we summarize the structure and biological effects of linear and angular psoralens. These compounds exhibit interesting biological effects on the cell cycle, apoptosis and differentiation. These molecules should be considered promising drugs in ... |
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Simultaneous determination of psoralen and isopsoralen in plasma and Chinese medicine Xian Ling Gu Bao capsule by using HPLC-DAD coupled with alternating trilinear decomposition algorithm.
Anal. Chim. Acta 650(2) , 160-6, (2009) A method using high performance liquid chromatography with photodiode-array detection (HPLC-DAD) coupled with alternating trilinear decomposition (ATLD) algorithm was proposed for simultaneous determination of psoralen and isopsoralen in plasma and Chinese me... |
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Relative photomutagenicity of furocoumarins and limettin in the hypoxanthine phosphoribosyl transferase assay in V79 cells.
Chem. Res. Toxicol. 22(9) , 1639-47, (2009) Furocoumarins are phototoxic and photomutagenic natural plant constituents found in many medicinal plants and food items. Because plants contain mixtures of several furocoumarins, there is a need for a comparative risk assessment of a large number of furocoum... |
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Application of dearomatization strategy on the synthesis of furoquinolinone and angelicin derivatives.
Org. Lett. 14(8) , 2114-7, (2012) The oxidative dearomatization of 3-(3-alkynyl-4-hydroxyphenyl)propanoic acid is combined with a cascade transition-metal catalyzed cyclization/addition/aromatization/lactamization sequence, which provides a novel approach to prepare furoquinolinone and angeli... |
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Simultaneous quantification of psoralen and isopsoralen in rat plasma by ultra-performance liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study after oral administration of Haigou Pill.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(27) , 3137-43, (2009) A rapid, specific and sensitive ultra-performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) method has been established for simultaneous quantitation of psoralen and isopsoralen in rat plasma. Plasma samples were pretreated by direct protein... |
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Accumulation of furanocoumarins by Bituminaria bituminosa in relation to plant development and environmental stress.
Plant Physiol. Biochem. 54 , 133-9, (2012) Bituminaria bituminosa (L.) C.H. Stirton (Fabaceae) accumulates high concentrations of the furanocoumarins (FCs) angelicin and psoralen, which protect against infection and herbivory. The effects on FC accumulation of the exposure of two populations of B. bit... |
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Pharmacokinetics, tissue distribution and excretion of coumarin components from Psoralea corylifolia L. in rats.
Arch. Pharm. Res. 33(2) , 225-30, (2010) Coumarin components from Psoralea corylifolia L. are novel drugs in which psoralen and isopsoralen are the active components. The pharmacokinetics, tissue distribution and excretion of the two compounds were studied by liquid chromatography-tandem mass spectr... |