阿尼西坦
阿尼西坦结构式
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常用名 | 阿尼西坦 | 英文名 | Aniracetam |
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| CAS号 | 72432-10-1 | 分子量 | 219.236 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 399.7±34.0 °C at 760 mmHg | |
| 分子式 | C12H13NO3 | 熔点 | −58 °C(lit.) | |
| MSDS | 中文版 | 闪点 | 195.5±25.7 °C |
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Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors.
J. Med. Chem. 53 , 2197-203, (2010) Glutamate receptors are the most prevalent excitatory neurotransmitter receptors in the vertebrate central nervous system and are important potential drug targets for cognitive enhancement and the treatment of schizophrenia. Allosteric modulators of AMPA rece... |
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Glutamate Receptors within the Mesolimbic Dopamine System Mediate Alcohol Relapse Behavior.
J. Neurosci. 35 , 15523-38, (2015) Glutamatergic input within the mesolimbic dopamine (DA) pathway plays a critical role in the development of addictive behavior. Although this is well established for some drugs of abuse, it is not known whether glutamate receptors within the mesolimbic system... |
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Development and validation of a liquid chromatographic method for the simultaneous determination of aniracetam and its related substances in the bulk drug and a tablet formulation.
J. Pharm. Biomed. Anal. 56(3) , 615-22, (2011) Simultaneous determination of aniracetam and its related impurities (2-pyrrolidinone, p-anisic acid, 4-p-anisamidobutyric acid and (p-anisoyl)-4-methyl-2-pyrrolidinone) was accomplished in the bulk drug and in a tablet formulation using a high performance liq... |
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Content determination of aniracetam in aniracetam inclusion complex by HPLC.
Artif. Cells Blood Substit. Immobil. Biotechnol. 37(3) , 143-5, (2009) We established a HPLC method for content determination of aniracetam in aniracetam inclusion complex. The chromato column was Agilent ODS (4.6mm x 150mm, 5 microm), the mobile phase was methanol-0.01 mol/L Potassium dihydrogen phosphate buffer solution (25:75... |
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Pharmacokinetics and bioequivalence study of aniracetam after single-dose administration in healthy Chinese male volunteers.
Arzneimittelforschung 58(10) , 497-500, (2008) The pharmacokinetics of aniracetam (CAS 72432-10-1) in Chinese healthy male volunteers was investigated for the first time. Twenty male volunteers were enrolled into this open, randomized, single blind two-sequence, two-period crossover study. Under fasting c... |
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Participation of hippocampal ionotropic glutamate receptors in histamine H(1) antagonist-induced memory deficit in rats.
Psychopharmacology 197(1) , 107-14, (2008) Pyrilamine, a selective histamine H(1) antagonist, impaired spatial memory, and decreased hippocampal theta activity during a radial maze task.We investigated the ameliorative effects of glutamatergic drugs on pyrilamine-induced spatial memory deficit and the... |
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Aniracetam. An overview of its pharmacodynamic and pharmacokinetic properties, and a review of its therapeutic potential in senile cognitive disorders.
Drugs Aging 4(3) , 257-73, (1994) Aniracetam is a member of the nootropic class of drugs, which have possible cognition enhancing effects. It appears to positively modulate metabotropic glutamate receptors and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate... |
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Benzoxazinones as potent positive allosteric AMPA receptor modulators: Part I
Bioorg. Med. Chem. Lett. 21(13) , 3923-6, (2011) AMPA receptors (AMPARs) are an increasingly important therapeutic target in the CNS. Aniracetam, the first identified potentiator of AMPARs, led to the rigid and more potent CX614. This lead molecule was optimized in order to increase affinity towards the AMP... |
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Treatment of insomnia by concomitant therapy with Zopiclone and Aniracetam in patients with cerebral infarction, cerebroatrophy, Alzheimer's disease and Parkinson's disease.
Psychiatry Clin. Neurosci. 52(2) , 198-200, (1998) For insomniac patients, sleeping drugs are used: in addition, concomitant therapy with other drugs has been tried in an effort to prevent a decrease in the effects due to long-term continuous use. This report presents the results of a study on the sleeping ef... |
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Substituted benzoxazinones as potent positive allosteric AMPA receptor modulators: Part II
Bioorg. Med. Chem. Lett. 21(13) , 3927-30, (2011) AMPA receptors (AMPARs) are an important therapeutic target in the CNS. A series of substituted benzoxazinone derivatives with good to very good in vitro activity as positive allosteric AMPAR modulators was synthesized and evaluated. The appropriate substitue... |