盐酸格拉司琼
盐酸格拉司琼结构式
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常用名 | 盐酸格拉司琼 | 英文名 | Granisetron hydrochloride |
|---|---|---|---|---|
| CAS号 | 107007-99-8 | 分子量 | 348.870 | |
| 密度 | 1.33g/cm3 | 沸点 | 532ºC at 760mmHg | |
| 分子式 | C18H25ClN4O | 熔点 | 290-292°C | |
| MSDS | 中文版 美版 | 闪点 | 275.6ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
J. Neurosci. 35 , 9580-94, (2015) Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for pain and substitution therapy. However, despite its wide clinical use, little is known about the synap... |
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In vitro percutaneous absorption enhancement of granisetron by chemical penetration enhancers.
Drug Dev. Ind. Pharm. 39(4) , 561-8, (2013) Granisetron (GRN), a potent antiemetic agent, is frequently used to prevent nausea and vomiting induced by cancer cytotoxic chemotherapy and radiation therapy.As part of our efforts to further modify the physicochemical properties of this market drug, with th... |
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Comparison of the efficacy of ondansetron and granisetron to prevent postoperative nausea and vomiting after laparoscopic cholecystectomy: a systematic review and meta-analysis.
Surg. Laparosc. Endosc. Percutan. Tech. 23(1) , 79-87, (2013) Our purpose was to assess the prophylactic antiemetic effects of ondansetron versus granisetron for laparoscopic cholecystectomy.We searched Medline, Cochrane Central Register of Controlled Trials, PubMed, Embase, Science Citation Index Expanded, Foreign Medi... |
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Retraction record rocks community.
Nature 489(7416) , 346-7, (2012)
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A meta-analysis of prevention of postoperative nausea and vomiting: randomised controlled trials by Fujii et al. compared with other authors.
Anaesthesia 67(10) , 1076-90, (2012) The population sampling in randomised controlled trials by Fujii et al. have been shown to exhibit unusual distributions. This systematic review analysed the effectiveness of prophylactic antiemetics in trials by Fujii et al. compared with other authors. Gran... |
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Granisetron adjunct to fluvoxamine for moderate to severe obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled trial.
CNS Drugs 26(10) , 883-92, (2012) Several small studies have shown beneficial effects of ondansetron, a serotonin 5-HT(3) receptor antagonist, in the treatment of obsessive-compulsive disorder (OCD). The efficacy of other 5-HT(3) receptor antagonists in patients with OCD is still unclear. Gra... |
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Design and validation of a homogeneous time-resolved fluorescence cell-based assay targeting the ligand-gated ion channel 5-HT3A.
Anal. Biochem. 484 , 105-12, (2015) Ligand-gated ion channels (LGICs) are considered as attractive protein targets in the search for new therapeutic agents. Nowadays, this strategy involves the capability to screen large chemical libraries. We present a new Tag-lite ligand binding assay targeti... |
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Antiemetic effectiveness and safety of aprepitant in patients with hematologic malignancy receiving multiday chemotherapy.
Am. J. Health Syst. Pharm. 70(4) , 343-9, (2013) Antiemetic effectiveness and safety of aprepitant in patients with hematologic malignancy receiving multiday chemotherapy were evaluated.All data were retrospectively collected from the Kyushu University Hospital's electronic medical record system. Patients a... |
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Effectiveness of palonosetron for preventing delayed chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy in patients with gastrointestinal cancer.
Support Care Cancer 22(4) , 905-9, (2014) Patients with gastrointestinal cancer who were receiving moderately emetogenic chemotherapy (MEC) were switched from granisetron, a first-generation 5-hydroxytryptamine-3 receptor antagonist, to palonosetron at our hospital. In the present study, we compared ... |
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Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: a pilot, randomized, open-label clinical trial.
Integr. Cancer Ther. 11(3) , 204-11, (2012) Nausea and vomiting are among the most prevalent and disturbing side effects of chemotherapy. Therefore, there is a need for additional antiemetic agents that could effectively reduce chemotherapy-induced nausea and vomiting (CINV), whether alone or in combin... |