甲磺酸酚妥拉明
甲磺酸酚妥拉明结构式
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常用名 | 甲磺酸酚妥拉明 | 英文名 | Phentolamine mesilate |
|---|---|---|---|---|
| CAS号 | 65-28-1 | 分子量 | 377.458 | |
| 密度 | N/A | 沸点 | 551ºC at 760 mmHg | |
| 分子式 | C18H23N3O4S | 熔点 | 180-182 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 287ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Vasorelaxant activities of Danhong injection and their differential effects on the rat abdominal aorta and mesenteric artery.
J. Cardiovasc. Pharmacol. 65(1) , 62-71, (2015) Previous studies have found that Danhong injection (DHI), an extensively used herbal extract preparation in China, might be a powerful vasodilator. The aims of this study were to determine the vascular activity of DHI and its effects on arteries of different ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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In vivo support for the new concept of pulmonary blood flow-mediated CO2 gas excretion in the lungs.
Am. J. Physiol. Lung Cell. Mol. Physiol. 308 , L1224-36, (2015) To further examine the validity of the proposed concept of pulmonary blood flow-dependent CO2 gas excretion in the lungs, we investigated the effects of intramediastinal balloon catheterization-, pulmonary artery catheterization-, or isoprenaline (ISP)-induce... |
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Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells.
J. Neuroimmunol. 259(1-2) , 8-16, (2013) The vaginal epithelium provides a barrier to pathogens and recruits immune defenses through the secretion of cytokines and chemokines. Several studies have shown that mucosal sites are innervated by norepinephrine-containing nerve fibers. Here we report that ... |
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Noradrenergic but not cholinergic modulation of olfactory bulb during processing of near threshold concentration stimuli.
Behav. Neurosci. 126(5) , 720-8, (2012) Neuromodulatory systems such as noradrenaline (NE), acetylcholine (ACh), and serotonin (5HT) serve important functions in sensory perception. We use the olfactory bulb (OB) as a model system to study the roles of individual neuromodulators in sensory percepti... |
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Effects of phentolamine infusion during selective cerebral perfusion in neonatal piglets.
Ann. Thorac. Surg. 96(6) , 2203-9, (2013) An optimal selective cerebral perfusion protocol in pediatric cardiac surgery is unknown. Phentolamine is frequently used in pediatric cardiopulmonary bypass. We sought to determine the effects of continuous phentolamine infusion during selective cerebral per... |
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Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma
Toxicol. Appl. Pharmacol. 273(3) , 456-63, (2013) In humans, hibernoma is a very rare, benign neoplasm of brown adipose tissue (BAT) that typically occurs at subcutaneous locations and is successfully treated by surgical excision. No single cause has been accepted to explain these very rare human tumors. In ... |