4-胺-2,2,6,6-四甲基二苯哌酯
4-胺-2,2,6,6-四甲基二苯哌酯结构式
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常用名 | 4-胺-2,2,6,6-四甲基二苯哌酯 | 英文名 | 4-amino-tempo |
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| CAS号 | 14691-88-4 | 分子量 | 171.260 | |
| 密度 | 0.962g/cm3 | 沸点 | 98 °C / 4mmHg | |
| 分子式 | C9H19N2O | 熔点 | 37-39°C | |
| MSDS | 中文版 美版 | 闪点 | 39 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Synthesis of Nanogels via Cell Membrane-Templated Polymerization.
Small 11 , 4309-13, (2015) The synthesis of biomimetic hydrogel nanoparticles coated with a natural cell membrane is described. Compared to the existing strategy of wrapping cell membranes onto pre-formed nanoparticle substrates, this new approach forms the cell membrane-derived vesicl... |
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Design and synthesis of digitally encoded polymers that can be decoded and erased.
Nat. Commun. 6 , 7237, (2015) Biopolymers such as DNA store information in their chains using controlled sequences of monomers. Here we describe a non-natural information-containing macromolecule that can store and retrieve digital information. Monodisperse sequence-encoded poly(alkoxyami... |
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Different effectiveness of piperidine nitroxides against oxidative stress induced by doxorubicin and hydrogen peroxide.
Cell Biol. Toxicol. 24(1) , 101-12, (2008) The piperidine nitroxides Tempamine and Tempace have been studied for their effect on doxorubicin (DOX) and hydrogen peroxide (H(2)O(2)) cytotoxicity in immortalized B14 cells, a model for neoplastic phenotype. The significance for nitroxide performance of th... |
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Ion exchange in alginate gels--dynamic behaviour revealed by electron paramagnetic resonance.
Soft Matter 11 , 8968-74, (2015) The formation of alginate gel from low molecular weight alginate and very low molecular weight alginate in the presence of divalent cations was investigated using Electron Paramagnetic Resonance (EPR) spectroscopy. The transition from sol to gel in the presen... |
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Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.
Antimicrob. Agents Chemother. 54 , 1042-6, (2010) Peroxidic antimalarials such as the semisynthetic artemisinins are critically important in the treatment of drug-resistant malaria. Nevertheless, their peroxide bond-dependent mode of action is still not well understood. Using combination experiments with cul... |
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Silica-installed redox nanoparticles for novel oral nanotherapeutics - improvement in intestinal delivery with anti-inflammatory effects.
J. Drug Target. 22(7) , 638-47, (2014) Silica nanoparticles were synthesized via a sol-gel method in which tetraethyl orthosilicate was hydrolyzed by the alkaline core of the nitroxide radical-containing nanoparticle (RNP). The silica nanoparticles were successively captured in the RNP core to obt... |
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Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors.
J. Med. Chem. 50 , 2137, (2007) We report on the design, synthesis, and evaluation of a series of furanyl-salicyl-nitroxide derivatives as effective chemical probes for second-site screening against phosphotyrosine phosphatases (PTPs) using NMR-based techniques. The compounds have been test... |
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Nano-Drugs Based on Nano Sterically Stabilized Liposomes for the Treatment of Inflammatory Neurodegenerative Diseases.
PLoS ONE 10 , e0130442, (2015) The present study shows the advantages of liposome-based nano-drugs as a novel strategy of delivering active pharmaceutical ingredients for treatment of neurodegenerative diseases that involve neuroinflammation. We used the most common animal model for multip... |
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Stent-based tempamine delivery on neointimal formation in a porcine coronary model.
Acute Card. Care 8(4) , 210-6, (2006) Tempamine is one of new class of antioxidant agents, the nitroxides, which have shown a wide range of biological effects like suppressing free radical driven reactions to maintain cell functions. The objectives of this study were to evaluate the effect of a b... |
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Modulation of streptonigrin cytotoxicity by nitroxide SOD mimics.
Free Radic. Biol. Med. 17(5) , 379-88, (1994) Nitroxides are cell-permeable, stable radicals that react readily with paramagnetic species such as transition metals or short-lived free radicals, though not generally with diamagnetic molecules. Nitroxides can undergo one-electron selective redox reactions ... |