ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2
ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2结构式
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常用名 | ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2 | 英文名 | Mastoparan 7 trifluoroacetate salt |
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| CAS号 | 145854-59-7 | 分子量 | 1421.81 | |
| 密度 | 1.154g/cm3 | 沸点 | 1649.9ºC at 760mmHg | |
| 分子式 | C67H124N18O15 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 951.6ºC |
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Activation of GTP formation and high-affinity GTP hydrolysis by mastoparan in various cell membranes. G-protein activation via nucleoside diphosphate kinase, a possible general mechanism of mastoparan action.
Biochem. Pharmacol. 51 , 217-223, (1996) The wasp venom, mastoparan (MP), is a direct activator of reconstituted pertussis toxin-sensitive G-proteins and of purified nucleoside diphosphate kinase (NDPK) [E.C. 2.6.4.6.]. In HL-60 membranes, MP activates high-affinity GTPase [E.C. 3.6.1.-] and NDPK-ca... |
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The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis.
J. Biol. Chem. 270 , 12869, (1995) Mastoparan, a tetradecapeptide found in wasp venom that stimulates G-proteins, increases insulin secretion from beta-cells. In this study, we have examined the role of heterotrimeric G-proteins in mastoparan-induced insulin secretion from the insulin-secretin... |
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Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase.
Biochemistry 304 , 377-383, (1994) The wasp venom, mastoparan (MP), activates reconstituted pertussis toxin (PTX)-sensitive G-proteins in a receptor-independent manner. We studied the effects of MP and its analogue, mastoparan 7 (MP 7), on G-protein activation in HL-60 cells and a reconstitute... |
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Drosophila GoLoco-protein Pins is a target of Galpha(o)-mediated G protein-coupled receptor signaling.
Mol. Biol. Cell 20(17) , 3865-77, (2009) G protein-coupled receptors (GPCRs) transduce their signals through trimeric G proteins, inducing guanine nucleotide exchange on their Galpha-subunits; the resulting Galpha-GTP transmits the signal further inside the cell. GoLoco domains present in many prote... |