苯甲酰芽子碱-d3
苯甲酰芽子碱-d3结构式
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常用名 | 苯甲酰芽子碱-d3 | 英文名 | Benzoylecgonine-d3 solution |
|---|---|---|---|---|
| CAS号 | 115732-68-8 | 分子量 | 292.34500 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C16H16D3NO4 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 11ºC | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery.
PLoS ONE 10(1) , e0116766, (2015) Acute and chronic pain conditions are often debilitating, inflicting severe physiological, emotional and economic costs and affect a large percentage of the global population. However, the development of therapeutic analgesic agents based primarily on targete... |
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Monoamine receptor agonists, acting preferentially at presynaptic autoreceptors and heteroreceptors, downregulate the cell fate adaptor FADD in rat brain cortex.
Neuropharmacology 89 , 204-14, (2014) FADD is a crucial adaptor of death receptors that can engage apoptosis or survival actions (e.g. neuroplasticity) through its phosphorylated form (p-FADD). Although FADD was shown to participate in receptor mechanisms related to drugs of abuse, little is know... |
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Adenylyl cyclases 5 and 6 underlie PIP3-dependent regulation.
FASEB J. 29 , 3458-71, (2015) Many different neurotransmitters and hormones control intracellular signaling by regulating the production of the second messenger cAMP. The function of the broadly expressed adenylyl cyclases (ACs) 5 and 6 is regulated by either stimulatory or inhibitory G p... |
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Effects of indole-3-carbinol on clonidine-induced neurotoxicity in rats: Impact on oxidative stress, inflammation, apoptosis and monoamine levels.
Neurotoxicology 44 , 48-57, (2014) The relationship between inflammation, oxidative stress and the incidence of depression had been well studied. Indole-3-carbinol (I3C), a natural active compound found in cruciferous vegetables, was shown to have anti-oxidant and anti-inflammatory activities.... |
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Noradrenaline-mediated facilitation of inhibitory synaptic transmission in the dorsal horn of the rat spinal cord involves interlaminar communications.
Eur. J. Neurosci. 42 , 2654-65, (2015) In the dorsal horn of the spinal cord (DH), noradrenaline (NA) is released by axons originating from the locus coeruleus and induces spinal analgesia, the mechanisms of which are poorly understood. Here, the effects of NA on synaptic transmission in the deep ... |
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Effects of low-dose clonidine on cardiovascular and autonomic variables in adolescents with chronic fatigue: a randomized controlled trial.
BMC Pediatr. 15 , 117, (2015) Chronic Fatigue Syndrome (CFS) is a common and disabling condition in adolescence with few treatment options. A central feature of CFS is orthostatic intolerance and abnormal autonomic cardiovascular control characterized by sympathetic predominance. We hypot... |
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Bioceramic microneedles with flexible and self-swelling substrate.
Eur. J. Pharm. Biopharm. 94 , 404-10, (2015) To reduce the effort required to penetrate the skin and optimize drug release profiles, bioceramic microneedle arrays with higher-aspect-ratio needles and a flexible and self-swelling substrate have been developed. Swelling of the substrate can assist in sepa... |
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Comparison of the effects of clonidine, loperamide and metoclopramide in two models of gastric emptying in the rat.
Fundam. Clin. Pharmacol. 29(1) , 86-94, (2015) Several methods are used to evaluate gastric emptying (GE) in rats, which is an important endpoint in preclinical drug development. Although phenol red model or monitoring of plasma acetaminophen levels are well-established procedures for GE assessment, their... |
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Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia.
Addict. Biol. 20(2) , 275-84, (2015) Opioids represent effective drugs for the relief of pain, yet chronic opioid use often leads to a state of increased sensitivity to pain that is exacerbated during withdrawal. A sensitization of pain-related negative affect has been hypothesized to closely in... |
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Discriminative stimulus effects of the novel imidazoline I₂ receptor ligand CR4056 in rats.
Sci. Rep. 4 , 6605, (2014) This study examined whether a novel imidazoline I₂ receptor ligand CR4056 could serve as a discriminative stimulus and whether it shares similar discriminative stimulus effects with other reported I₂ receptor ligands. Eight male Sprague-Dawley rats were train... |