2-(对戊基桂皮酰基)胺-4-氯代苯甲酸
2-(对戊基桂皮酰基)胺-4-氯代苯甲酸结构式
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常用名 | 2-(对戊基桂皮酰基)胺-4-氯代苯甲酸 | 英文名 | ONO-RS-082 |
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| CAS号 | 99754-06-0 | 分子量 | 371.85700 | |
| 密度 | 1.247g/cm3 | 沸点 | 580.5ºC at 760mmHg | |
| 分子式 | C21H22ClNO3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 304.9ºC | |
| 符号 |
GHS09 |
信号词 | Warning |
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Role of phospholipase A(2) in retrograde transport of ricin.
Toxins (Basel.) 3(9) , 1203-19, (2011) Ricin is a protein toxin classified as a bioterror agent, for which there are no known treatment options available after intoxication. It is composed of an enzymatically active A-chain connected by a disulfide bond to a cell binding B-chain. After internaliza... |
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A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking.
Traffic 11(12) , 1530-6, (2010) We have investigated the role of phospholipase A(2) (PLA(2) ) enzymes in generating membrane tubules at the trans-Golgi network (TGN). Constitutive TGN membrane tubules and those induced by over-expressing kinase dead protein kinase D were inhibited by the PL... |
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Pyrimidine nucleotide-stimulated thromboxane A2 release from cultured glia.
Cell. Mol. Neurobiol. 18(5) , 477-86, (1998) 1. Uridine triphosphate (UTP), uridine diphosphate (UDP), cytidine triphosphate (CTP), and deoxythymidine triphosphate (TTP) caused concentration-dependent increases in the release of thromboxane A2 (TXA2) from cultured glia prepared from the newborn rat cere... |
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Role and regulation of prostaglandin synthesis in the mitogenic response of ovarian granulosa cells to transforming growth factor alpha.
Adv. Exp. Med. Biol. 407 , 509-14, (1997)
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Simultaneous activation of PLA2 and PLC are required to promote acrosomal reaction stimulated by progesterone via G-proteins.
Mol. Reprod. Dev. 70(1) , 58-63, (2005) The acrosome reaction (AR) is a special exocytotic process promoted by signal transduction pathways studied in many laboratories. Progesterone (P4) is one of the trigger molecules proposed. Upon the binding of P4 to its receptor, several molecules could be ac... |
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Acrosome reaction stimulated by the GTP non-hydrolizable analogue GTP gamma S is blocked by phospholipase A2 inhibitors in human spermatozoa.
Int. J. Androl. 19(4) , 248-52, (1996) Phospholipase A2 (PLA2, EC 3.1.1.4) is involved in the cascade of signalling events leading to the acrosome reaction in human spermatozoa. In order to study the role of PLA2 in the acrosome reaction triggered by GTP gamma S, a non-hydrolizable analogue of GTP... |
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Arachidonyltrifluoromethy ketone, a phospholipase A(2) antagonist, induces dispersal of both Golgi stack- and trans Golgi network-resident proteins throughout the cytoplasm.
Biochem. Biophys. Res. Commun. 281(2) , 582-8, (2001) Arachidonyltrifluoromethy ketone (AACOCF(3)), a phospholipase A(2) antagonist, reversibly induced dispersal of Golgi stack- and trans Golgi network (TGN)-resident proteins throughout the cytoplasm in NRK cells as followed by immunocytochemical staining of Man... |
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Lipoxygenase products regulate nitric oxide and inducible nitric oxide synthase production in interleukin-1beta stimulated vascular smooth muscle cells.
Hypertens. Res. 26(2) , 177-84, (2003) In cultured vascular smooth muscle cells (VSMCs), interleukin-1beta (IL-1beta) stimulates inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production. IL-1beta also activates phospholipase A2 (PLA2), and induces lipoxygenase (LOX) and c... |
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Regulation of the water channel aquaporin-1: isolation and reconstitution of the regulatory complex.
Cell Biol. Int. 28(1) , 7-17, (2004) Aquaporins (AQP) are involved in rapid and active gating of water across biological membranes. The molecular regulation of AQP is unknown. Here we report the isolation, identification and reconstitution of the regulatory complex of AQP-1. AQP-1 and Galphai3 h... |
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Human fetal skin fibroblast migration stimulated by the autocrine growth factor bFGF is mediated by phospholipase A(2) via arachidonic acid without the involvement of pertussis toxin-sensitive G-protein.
Biochem. Biophys. Res. Commun. 272(3) , 648-52, (2000) We reported previously that human fetal skin fibroblast migration into a denuded area was stimulated by an autocrine factor, basic fibroblast growth factor (bFGF). Since the signal transduction pathway of this migration is unknown, we attempted to clarify it ... |