7-胺基去乙酰氧基头胞烷酸
7-胺基去乙酰氧基头胞烷酸结构式
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常用名 | 7-胺基去乙酰氧基头胞烷酸 | 英文名 | 6-Aminochrysene |
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| CAS号 | 2642-98-0 | 分子量 | 243.303 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 501.2±19.0 °C at 760 mmHg | |
| 分子式 | C18H13N | 熔点 | 209-211 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 286.9±16.8 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Role of human N-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium NM6001 and NM6002.
Carcinogenesis 20(6) , 1079-83, (1999) Human NAT1 and NAT2 genes were subcloned into pACYC184 vector and the plasmids thus obtained were introduced into Salmonella typhimurium O-acetyltransferase-deficient strain NM6000 (TA1538/1, 8-DNP/pSK1002), establishing new strains NM6001 and NM6002, respect... |
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Quantitative microspectrofluorimetry study of the "blocking effect" of 6-aminochrysene on benzo[a]pyrene metabolism using single living cells.
Toxicology 29(4) , 345-56, (1984) By microspectrofluorimetry on single living cells (murine fibroblasts 3T3), we have obtained monoexponential decreases of fluorescence intensity for benzo[a]pyrene (B[a]P) and 6-aminochrysene (6a-chrysene) metabolism. These kinetics are characteristics of B[a... |
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Determination of polycyclic aromatic amines in skin by liquid chromatography with electrochemical detection.
J. Chromatogr. A. 354 , 442-8, (1986)
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Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450.
Carcinogenesis 15(3) , 465-70, (1994) In order to address the hypothesis that 6-aminochrysene (6-AC) is converted to genotoxic products by cytochrome P450 enzymes via two activation pathways (N-hydroxylation and epoxidation), the activation of 6-AC and trans-1,2-dihydro-1,2-dihydroxy-6-aminochrys... |
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Induction of mutations at the hypoxanthine phosphoribosyl transferase (HPRT) locus in AHH-1 human lymphoblastoid cells.
Mutat. Res. 310(1) , 45-54, (1994) Cells from the human lymphoblastoid cell line, AHH-1, were exposed to two direct-acting mutagens, ethyl methanesulfonate (EMS) and ethyl nitrosourea (ENU), and to three carcinogens that require metabolic activation to an electrophile, benzo[a]pyrene (B(a)P), ... |
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Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat.
Mutagenesis 20(1) , 23-8, (2005) Rats were exposed to black tea (2.5% w/v) as their sole drinking liquid for either 1 day (short-term) or 1 month (long-term), while controls received water. After exposure, all animals received a single oral dose of 6-aminochrysene and urine was collected for... |
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Identification of 6-aminochrysene photoproducts and study of the effect of a humic acid and riboflavin on its photolysis.
J. Photochem. Photobiol. B, Biol. 72(1-3) , 95-100, (2003) The effect of the photosensitizer riboflavin (0, 10, 25, 50, 100 microM) and a river humic acid (0, 20, 40, 80 ppm) on the photolysis of 6-aminochrysene (6AC) in 10 mM PBS solution (pH 7.0) was studied. The presence of riboflavin significantly enhanced photol... |
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Comparing cytotoxicity and genotoxicity in HaCaT cells caused by 6-aminochrysene and 5,6-chrysenequinone under ultraviolet A irradiation.
Environ. Toxicol. Chem. 25(7) , 1920-5, (2006) Chrysene is one of the basic polycyclic aromatic hydrocarbons that are toxic environmental pollutants. The photoproducts of 6-aminochrysene (6AC) include 5,6-chrysenequinone (5,6-CQ) along with some minor products. In this study, cytotoxicity and genotoxicity... |
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Modulation of rat hepatic aryl hydrocarbon hydroxylase by various flavones and polycyclic aromatic hydrocarbons.
Pharmacology 31(4) , 194-202, (1985) The microsomal cytochrome P-450-dependent aryl hydrocarbon hydroxylase is important in the detoxification of polycyclic hydrocarbons as well as their activation to cytotoxic or carcinogenic derivatives. We have studied compounds that can modify the activity o... |
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Mutagenicity of bay-region amino-substituted cyclopenta[a]phenanthrenes and 2- and 5-aminochrysene.
Mutat. Res. 492(1-2) , 7-11, (2001) The relative mutagenic potentials of 11-amino-16,17-dihydro-15H-cyclopenta[a]phenanthrene, its 17-keto derivative, and 2- and 5-aminochrysene have been compared in Salmonella typhimurium TA98 and TA100 in the presence of a postmitochondrial liver preparation ... |