二苯甲醇
二苯甲醇结构式
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常用名 | 二苯甲醇 | 英文名 | Benzhydrol |
|---|---|---|---|---|
| CAS号 | 91-01-0 | 分子量 | 184.23 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 299.0±0.0 °C at 760 mmHg | |
| 分子式 | C13H12O | 熔点 | 65-67 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 140.8±15.1 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Semi-quantitative profile of regioisomeric monohydroxydiphenylmethane metabolites in rat urine, faeces and bile.
Xenobiotica 11(6) , 425-32, (1981) 1. Urine and faeces, and two-hour bile samples from adult male rats dosed with [14C]diphenylmethane were analysed for benzhydrol and 2- and 4-hydroxydiphenyl-methane by silica gel GF t.l.c. and 14C-determination. 2. Mean values of 48.4% and 17.7% of the admin... |
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Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors.
Bioorg. Med. Chem. 19 , 1930-1949, (2011) To obtain small and efficient squalene synthase inhibitors, a flexible 2-aminobenzhydrol open form structure was designed and showed potent inhibitory activity comparable to 4,1-benzoxazepin compounds. Further chemical modification led to the discovery of a n... |
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Calorimetric study of glass transition in molecular liquids consisting of globular associates: dicyclorohexylmethanol and tricyclohexylmethanol.
J. Phys. Chem. B 116(13) , 3938-43, (2012) Heat capacities of liquids and liquid-quenched glasses (LQGs) of dicyclorohexylmethanol (DCHM) and tricyclohexylmethanol (TCHM) were measured by adiabatic calorimetry. Upon cooling the liquid compounds, they undergo glass transitions around 250 and 265 K, res... |
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Discovery of novel tricyclic compounds as squalene synthase inhibitors.
Bioorg. Med. Chem. 20(9) , 3072-93, (2012) In the present article, we have reported the design, synthesis, and identification of highly potent benzhydrol derivatives as squalene synthase inhibitors (compound 1). Unfortunately, the in vivo efficacies of the compounds were not enough for acquiring the c... |
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Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: novel, highly potent and orally efficacious squalene synthase inhibitors.
Bioorg. Med. Chem. 19(17) , 5207-24, (2011) We have recently reported the discovery of the new benzhydrol template, which has a highly potent inhibitory activity for squalene synthase, as typified by compound 1 (SSI IC(50)=0.85 nM). However, it was composed of a pair of easy rotatable atropisomers. In ... |
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[Determination of dimedrol and benzhydrol in the urine by high efficient liquid chromatographic method].
Sud. Med. Ekspert. 23(2) , 40-2, (1980)
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Degradation of DDT and its analogs by Pseudomonas aeruginosa 640x.
Biol. Bull. Acad. Sci. USSR 7(2) , 143-51, (1980) The possibility of complete degradation of DDT by Pseudomonas aeruginosa 640x was demonstrated in principle. A study of the conditions of degradation of DDT by this culture was made. It was demonstrated that only dechlorination of DDT to DDD is accomplished w... |
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Kinetics of the hydrolysis of drugs containing the diphenyl-methyl-ether group.
Mater. Med. Pol. 17(2) , 98-102, (1985)
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Alkylation of alcohols for gas chromatographic analysis by a phase transfer catalysis technique. Evaluation of benzhydrol benzylation in a one-phase system.
Acta Pharm. Suec. 16(4) , 247-62, (1979)
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Genotoxic activation of benzophenone and its two metabolites by human cytochrome P450s in SOS/umu assay.
Mutat. Res. 519(1-2) , 199-204, (2002) The genotoxic potential of benzophenone and its metabolically related compounds, benzhydrol and p-benzoylphenol, was investigated using human cytochrome P450 (P450) enzymes. Benzophenone and its two metabolites (0.1-1mM) showed a suppression of bacterial grow... |