4-溴甲基-6,7-二甲氧基香豆素
4-溴甲基-6,7-二甲氧基香豆素结构式
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常用名 | 4-溴甲基-6,7-二甲氧基香豆素 | 英文名 | 4-(Bromomethyl)-6,7-dimethoxy-2H-chromen-2-one |
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| CAS号 | 88404-25-5 | 分子量 | 299.117 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 417.1±45.0 °C at 760 mmHg | |
| 分子式 | C12H11BrO4 | 熔点 | 212-216 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 206.0±28.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Simultaneous radiometric and fluorimetric detection of lauric acid metabolites using high-performance liquid chromatography following esterification with 4-bromomethyl-6,7-dimethoxycoumarin in human and rat liver microsomes.
J. Chromatogr. B, Biomed. Appl. 681(2) , 233-9, (1996) The formation of (omega-1)-hydroxylauric acid from lauric acid (LA) can be used as an indicator of the activity of cytochrome P450 2E1 (CYP2E1) in rat and human liver microsomes. A high-performance liquid chromatographic (HPLC) method that is capable of ident... |
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Labeling of immunoglobulins with bifunctional, sulfhydryl-selective, and photoreactive coumarins.
Bioconjug. Chem. 4(4) , 300-4, (1993) 4-(Bromomethyl)-6,7-dimethoxy-2-oxo-2H-benzopyran (1a) and 4-(bromomethyl)-7-methoxy-2-oxo-2H-benzopyran (1b) and their iodo analogs (2) reacted selectively with the sulfhydryl groups generated in a limited reduction of the hinge disulfide bonds of an immunog... |
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Investigation of derivatization reagents for the analysis of diarrhetic shellfish poisoning toxins by liquid chromatography with fluorescence detection.
Nat. Toxins 2(5) , 302-11, (1994) Several derivatization reagents for the conversion of okadaic acid and related DSP toxins to fluorescent derivatives for analysis by liquid chromatography have been examined, viz: 9-anthryldiazomethane (ADAM), 1-pyrenyldiazomethane (PDAM), 4-diazomethyl-7-met... |
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Characterization of the single Ca(2+)-binding site on the Ca(2+)-ATPase reconstituted with short- or long-chain phosphatidylcholines.
Biochem. J. 304 ( Pt 2) , 569-75, (1994) On reconstitution of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum into bilayers of dimyristoleoylphosphatidylcholine [di(C14:1)PC] or dinervonylphosphatidylcholine [di(C24:1)PC] the stoichiometry of Ca2+ binding changes from the usual two Ca2+ ... |
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Labeling the (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum with 4-(bromomethyl)-6,7-dimethoxycoumarin: detection of conformational changes.
Biochemistry 31(26) , 6023-31, (1992) The (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum was labeled with 4-(bromomethyl)-6,7-dimethoxycoumarin. It was shown that a single cysteine residue (Cys-344) was labeled on the ATPase, with a 25% reduction in steady-state ATPase activity and no reduction i... |
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Simultaneous determination of mycophenolic acid and valproic acid based on derivatization by high-performance liquid chromatography with fluorescence detection.
Biomed. Chromatogr. 20(4) , 319-26, (2006) A reliable and validated reversed-phase high-performance liquid chromatography (HPLC) method using fluorescence detection is reported for the simultaneous quantitation of mycophenolic acid (MPA) and valproic acid (VPA) in human plasma. The method is based on ... |
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1-(Tetrahydro-2-furanyl)-5-fluorouracil (Ftorafur) determined in rat hair as an index of drug exposure.
J. Pharm. Sci. 82(12) , 1272-4, (1993) The fluorescence derivatization of 1-(tetrahydro-2-furanyl)-5-fluorouracil (Ftorafur, FT) with 4-bromomethyl-6,7-dimethoxycoumarin (BrMdmc) with 18-crown-6 as catalyst was utilized for a sensitive and selective liquid chromatographic method to determine the c... |
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Determination of 3-deazaguanine in mice plasma by high-performance liquid chromatography.
J. Chromatogr. A. 309 , 403, (1984)
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A simple and sensitive method for the determination of fibric acids in the liver by liquid chromatography.
Biol. Pharm. Bull. 37(1) , 105-12, (2014) Fibrates are used in biochemical and pharmacological studies as bioactive tools. Nevertheless, most studies have lacked information concerning the concentrations of fibric acids working inside tissues because a simple and sensitive method is not available for... |
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Quantitation of the glutathione in human peripheral blood by matrix-assisted laser desorption ionization time-of-flight mass spectrometry coupled with micro-scale derivatization.
Anal. Chim. Acta 690(2) , 209-14, (2011) Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been broadly applied to analyze high-molecular-weight compound (such as polymer or proteomic research) but seldom used for low-molecular-weight compound analysis. ... |