5,5,5-三氟-DL-亮氨酸
5,5,5-三氟-DL-亮氨酸结构式
|
常用名 | 5,5,5-三氟-DL-亮氨酸 | 英文名 | 5,5,5-TRIFLUORO-DL-LEUCINE |
|---|---|---|---|---|
| CAS号 | 2792-72-5 | 分子量 | 185.14400 | |
| 密度 | 1.294g/cm3 | 沸点 | 217.4ºC at 760 mmHg | |
| 分子式 | C6H10F3NO2 | 熔点 | 273ºC | |
| MSDS | 中文版 美版 | 闪点 | 85.3ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
|
The first isolation of two types of trifluoroleucine resistant mutants of Saccharomyces servazzii.
Biotechnol. Lett. 25(20) , 1735-8, (2003) Saccharomyces servazzii plays a crucial role in the making of Japanese radish pickles. To make more flavorsome pickles, we sought to generate trifluoroleucine-resistant mutants of S. servazzii. The three resulting mutants could be classified into two types: o... |
|
|
Construction of two new vectors for transformation of laboratory, natural and industrial Saccharomyces cerevisiae strains to trifluoroleucine and G418 resistance.
Folia Microbiol. (Praha) 49(5) , 534-8, (2004) Two new plasmids, pEC3 and pECkan, were constructed and their use in yeast transformation described. Both plasmids are derivative of the pRS416 vector, in which the URA3 auxotrophic marker was replaced by the LEU4* gene (pEC3) or the kanMX4 gene (pECkan). pEC... |
|
|
Self-association and membrane-binding behavior of melittins containing trifluoroleucine.
J. Am. Chem. Soc. 123(30) , 7407-13, (2001) We have investigated the effect of trifluoroleucine substitution on the membrane-binding and tetramerization behavior of melittin. Analogues were synthesized in which Leu 9, Leu 13, and all four intrinsic leucine residues of melittin were replaced by 5,5,5-tr... |
|
|
Biosynthesis and stability of coiled-coil peptides containing (2S,4R)-5,5,5-trifluoroleucine and (2S,4S)-5,5,5-trifluoroleucine.
ChemBioChem. 10(1) , 84-6, (2009)
|
|
|
Stabilization of coiled-coil peptide domains by introduction of trifluoroleucine.
Biochemistry 40(9) , 2790-6, (2001) Substitution of leucine residues by 5,5,5-trifluoroleucine at the d-positions of the leucine zipper peptide GCN4-p1d increases the thermal stability of the coiled-coil structure. The midpoint thermal unfolding temperature of the fluorinated peptide is elevate... |
|
|
Oxazoline-oxazinone oxidative rearrangement. divergent syntheses of (2S,3S)-4,4,4-trifluorovaline and (2S,4S)-5,5,5-Trifluoroleucine.
J. Org. Chem. 74(15) , 5510-5, (2009) Stereoselective syntheses of the valuable fluorinated amino acids (2S,3S)-4,4,4-trifluorovaline and (2S,4S)-5,5,5-trifluoroleucine have been achieved starting from 4,4,4-trifluoro-3-methylbutanoic acid by using a conceptually simple transformation: conversion... |
|
|
Trifluoroleucine resistance and regulation of alpha-isopropyl malate synthase in Saccharomyces cerevisiae.
Mol. Gen. Genet. 261(1) , 152-60, (1999) Seven spontaneous Saccharomyces cerevisiae mutants that express dominant resistance to 5,5,5-trifluoro-DL-leucine have been characterised at the molecular level. The gene responsible for the resistance was cloned from one of the mutants (FSC2.4). Determinatio... |
|
|
Influence of global fluorination on chloramphenicol acetyltransferase activity and stability.
Biotechnol. Bioeng. 94(5) , 921-30, (2006) Varied levels of fluorinated amino acid have been introduced biosynthetically to test the functional limits of global substitution on enzymatic activity and stability. Replacement of all the leucine (LEU) residues in the enzyme chloramphenicol acetyltransfera... |
|
|
Mutations affecting regulation of methionine biosynthetic genes isolated by use of met-lac fusions.
J. Bacteriol. 151(2) , 609-19, (1982) Fusions of the lac genes to the promoters of four structural genes in the methionine biosynthetic pathway, metA, metB, metE, and metF, were obtained by the use of the Mu d(Ap lac) bacteriophage. The levels of beta-galactosidase in these strains could be derep... |
|
|
A simple and efficient method for the resolution of all four diastereomers of 4,4,4-trifluorovaline and 5,5,5-trifluoroleucine.
J. Org. Chem. 67(5) , 1722-5, (2002)
|