亚硫酸氢钠甲萘醌
亚硫酸氢钠甲萘醌结构式
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常用名 | 亚硫酸氢钠甲萘醌 | 英文名 | Menadione sodiuM bisulfite |
|---|---|---|---|---|
| CAS号 | 130-37-0 | 分子量 | 276.241 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C11H9NaO5S | 熔点 | 121-124ºC | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
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Rapid Bioassay-Guided Isolation of Antibacterial Clerodane Type Diterpenoid from Dodonaea viscosa (L.) Jaeq.
Int. J. Mol. Sci. 16 , 20290-307, (2015) Plant extracts are complex matrices and, although crude extracts are widely in use, purified compounds are pivotal in drug discovery. This study describes the application of automated preparative-HPLC combined with a rapid off-line bacterial bioassay, using r... |
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S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity.
Chem. Biol. Interact. 202(1-3) , 136-45, (2013) Carbonyl reductase 1 (CBR1 or SDR21C1) is a ubiquitously-expressed, cytosolic, monomeric, and NADPH-dependent enzyme. CBR1 participates in apoptosis, carcinogenesis and drug resistance, and has a protective role in oxidative stress, cancer and neurodegenerati... |
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Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations.
Antimicrob. Agents Chemother. 59 , 2242-55, (2015) Together with vector control, chemotherapy is an essential tool for the control of visceral leishmaniasis (VL), but its efficacy is jeopardized by growing resistance and treatment failure against first-line drugs. To delay the emergence of resistance, the use... |
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Vitamins K interact with N-terminus α-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and α-synuclein.
Neurochem. Int. 62(1) , 103-12, (2013) In the last decades, a series of compounds, including quinones and polyphenols, has been described as having anti-fibrillogenic action on α-synuclein (α-syn) whose aggregation is associated to the pathogenesis of Parkinson's disease (PD). Most of these molecu... |
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CR108, a novel vitamin K3 derivative induces apoptosis and breast tumor inhibition by reactive oxygen species and mitochondrial dysfunction.
Toxicol. Appl. Pharmacol. 273(3) , 611-22, (2013) Vitamin K3 derivatives have been shown to exert anticancer activities. Here we show a novel vitamin K3 derivative (S)-2-(2-hydroxy-3-methylbutylthio)naphthalene-1,4-dione, which is named as CR108 that induces apoptosis and tumor inhibition through reactive ox... |
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Into the depths: Techniques for in vitro three-dimensional microtissue visualization.
Biotechniques 59 , 279-86, (2015) Three-dimensional (3-D) in vitro platforms have been shown to closely recapitulate human physiology when compared with conventional two-dimensional (2-D) in vitro or in vivo animal model systems. This confers a substantial advantage in evaluating disease mech... |
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Antimutagenic and antioxidant properties of plumbagin and other naphthoquinones.
Mutat. Res. 755(1) , 30-41, (2013) The structure-function relationships of the naphthoquinone phytochemicals, plumbagin, juglone, and menadione, have been studied with regard to antimutagenic and antioxidant activities. Antimutagenicity of these compounds was assessed by the Ames test and RNA ... |
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[The role of thiol antioxidants in restoring mitochondrial functions, modified by microbial metabolites].
Biofizika 57(5) , 820-6, (2012) The effects of phenolic acids of microbial origin on mitochondrial functions and the possibility of removing their effects by thiol antioxidants dithiotreitol and N-acethylcysteine were studied. The action of some phenolic acids on the redox state of NADH, th... |
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Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats.
J. Biol. Chem. 288(46) , 33071-80, (2013) Mice have the ability to convert dietary phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) and store the latter in tissues. A prenyltransferase enzyme, UbiA prenyltransferase domain-containing 1 (UBIAD1), is involved in this conversion. There is evid... |
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Cytoprotection of human endothelial cells from oxidant stress with CDDO derivatives: network analysis of genes responsible for cytoprotection.
Pharmacology 95 , 181-92, (2015) To identify drugs that may reduce the impact of oxidant stress on cell viability.Human umbilical vein endothelial cells were treated with 200 nmol/l CDDO-Im (imidazole) and CDDO-Me (methyl) after exposure to menadione and compared to vehicle-treated cells. Ce... |