盐霉素 A
盐霉素 A结构式
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常用名 | 盐霉素 A | 英文名 | Siomycin A |
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| CAS号 | 12656-09-6 | 分子量 | 1648.844 | |
| 密度 | 1.7±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C71H81N19O18S5 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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A novel mode of FoxM1 regulation: positive auto-regulatory loop.
Cell Cycle 8(12) , 1966-7, (2009) Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisi... |
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Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells.
PLoS ONE 4(5) , e5592, (2009) Forkhead box M1 (FoxM1) oncogenic transcription factor represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Recently, using a cell-based assay system we identified thiazole antibio... |
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The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer.
J. Mol. Med. 91(2) , 237-48, (2013) Loss of cell cycle control is a prerequisite for cancer onset and progression. In prostate cancer, increased activity of cell cycle genes has been associated with prognostic parameters such as biochemical relapse and survival. The identification of novel onco... |
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Two-dimensional NMR spectroscopy of siomycin A. Proton--carbon-13 chemical shift correlation.
Eur. J. Biochem. 123(1) , 127-31, (1982) A trial application of a recent two-dimensional nuclear magnetic resonance experiment to the polypeptide antibiotic siomycin A is described. Proton--carbon-13 chemical shift correlation measures the proton and carbon-13 chemical shift for each directly bonded... |
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FOXM1: the Achilles' heel of cancer?
Nat. Rev. Cancer 8(3) , c1; author reply c2, (2008)
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Future roles for FoxM1 inhibitors in cancer treatments.
Future Oncol. 3(1) , 1-3, (2007)
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Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients.
Clin. Cancer Res. 17(21) , 6791-801, (2011) The transcription factor Forkhead box M1 (FoxM1) is a key regulator of cell-cycle progression. It is involved in the development of multiple organs, and we have previously reported on its important role for the mitotic entry of cerebellar granule neuron precu... |
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FoxM1 is a general target for proteasome inhibitors.
PLoS ONE 4(8) , e6593, (2009) Proteasome inhibitors are currently in the clinic or in clinical trials, but the mechanism of their anticancer activity is not completely understood. The oncogenic transcription factor FoxM1 is one of the most overexpressed genes in human tumors, while its ex... |
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Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway.
Neuro. Oncol. 13(6) , 622-34, (2011) Glioblastoma multiforme (GBM) is a devastating disease, and the current therapies have only palliative effect. Evidence is mounting to indicate that brain tumor stem cells (BTSCs) are a minority of tumor cells that are responsible for cancer initiation, propa... |
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New potential anti-cancer agents synergize with bortezomib and ABT-737 against prostate cancer.
Prostate 70(8) , 825-33, (2010) We previously described the identification of a transcriptional inhibitor ARC and FoxM1 inhibitors, thiazole antibiotics, Siomycin A and thiostrepton that were able to induce potent p53-independent apoptosis in cancer cell lines of different origin. Here, we ... |