N-亚硝基新烟草碱
N-亚硝基新烟草碱结构式
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常用名 | N-亚硝基新烟草碱 | 英文名 | N-nitrosoanabasine |
|---|---|---|---|---|
| CAS号 | 37620-20-5 | 分子量 | 191.230 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 380.2±35.0 °C at 760 mmHg | |
| 分子式 | C10H13N3O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 183.8±25.9 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A.
PLoS ONE 10(3) , e0120252, (2015) Evidence is accumulating that activation of the pancreatic endoplasmic reticulum kinase (PERK) in response to endoplasmic reticulum (ER) stress adapts tumor cells to the tumor microenvironment and enhances tumor angiogenesis by inducing vascular endothelial g... |
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Physiologically based pharmacokinetic modeling to predict drug-drug interactions involving inhibitory metabolite: a case study of amiodarone.
Drug Metab. Dispos. 43(2) , 182-9, (2014) Evaluation of drug-drug interaction (DDI) involving circulating inhibitory metabolites of perpetrator drugs has recently drawn more attention from regulatory agencies and pharmaceutical companies. Here, using amiodarone (AMIO) as an example, we demonstrate th... |
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Disparities in child mortality trends: what is the evidence from disadvantaged states in India? the case of Orissa and Madhya Pradesh.
Int J Equity Health 12 , 45, (2013) The Millennium Development Goals prompted renewed international efforts to reduce under-five mortality and measure national progress. However, scant evidence exists about the distribution of child mortality at low sub-national levels, which in diverse and dec... |
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Oral mucosal changes and nicotine disposition in users of Swedish smokeless tobacco products: a comparative study.
J. Oral. Pathol. Med. 23(4) , 161-7, (1994) The purpose of this study was to investigate the uptake and metabolism of nicotine by smokeless (oral) tobacco users and to find out if the less pronounced clinical changes in the oral mucosa in users of portion-bag packed oral moist snuff (snus) compared wit... |
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N'-Nitrosoanabasine (NAB).
IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 37 , 225-31, (1985)
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Immunotoxic effects of smokeless tobacco on the accessory cell function of rat oral epithelium.
Eur. J. Oral Sci. 105(1) , 45-51, (1997) Smokeless tobacco (ST) is known to adversely effect the oral mucosa, but knowledge about the influence on immune defence is limited. Few studies have investigated the effect of ST on the local immune response. In the present study, we have assessed the effect... |
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Carcinogenic tobacco-specific nitrosamines are present at unusually high levels in the saliva of oral snuff users in Sudan.
Carcinogenesis 13(6) , 1001-5, (1992) Exposure to tobacco-specific nitrosamines (TSNA) has been measured in the saliva of 12 users of Sudanese oral snuff (toombak). Using GC coupled to thermal energy analysis, levels of N'-nitrosonornicotine (NNN), N'-nitrosoanatabine (NAT), N'-nitrosoanabasine (... |
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Unusually high levels of carcinogenic tobacco-specific nitrosamines in Sudan snuff (toombak).
Carcinogenesis 12(6) , 1115-8, (1991) The aim of these studies was to determine the levels of carcinogenic tobacco specific nitrosamines (TSNA) in Sudanese oral snuff (toombak) as recent retrospective epidemiological studies suggested an association between the use of toombak and subsequent devel... |
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Regiospecificity in the metabolism of the homologous cyclic nitrosamines, N'-nitrosonornicotine and N'-nitrosoanabasine.
Carcinogenesis 3(10) , 1195-9, (1982) We compared the metabolism in the F-344 rat of the moderately potent esophageal carcinogen N'-nitrosonornicotine (NNN, 2'-(3-pyridyl)-N-nitrosopyrrolidine) and its weakly active homologue N'-nitrosoanabasine (NAB, 2'-(3-pyridyl)-N-nitrosopiperidine). Urine wa... |
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Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobacco.
J. Agric. Food Chem. 50(10) , 2793-7, (2002) Tobacco-specific nitrosamines (TSNA) are among the most important and abundant strongly carcinogenic agents in unburned tobacco. It has been established that 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces lung tumors in rodents independent of th... |