D-葡萄糖胺6-磷酸 钠盐
D-葡萄糖胺6-磷酸 钠盐结构式
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常用名 | D-葡萄糖胺6-磷酸 钠盐 | 英文名 | d-glucosamine 6-phosphate sodium salt |
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| CAS号 | 70442-23-8 | 分子量 | 281.13300 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C6H13NNaO8P | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Design and synthesis of novel cell wall inhibitors of Mycobacterium tuberculosis GlmM and GlmU.
Carbohydr. Res. 346(13) , 1714-20, (2011) GlmM and GlmU are key enzymes in the biosynthesis of UDP-N-acetyl-d-glucosamine (UDP-GlcNAc), an essential precursor of peptidoglycan and the rhamnose-GlcNAc linker region in the mycobacterial cell wall. These enzymes are involved in the conversion of two imp... |
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Evidence that adrenal hexose-6-phosphate dehydrogenase can effect microsomal P450 cytochrome steroidogenic enzymes.
Biochim. Biophys. Acta 1833(9) , 2039-44, (2013) The role of adrenal hexose-6-phosphate dehydrogenase in providing reducing equivalents to P450 cytochrome steroidogenic enzymes in the endoplasmic reticulum is uncertain. Hexose-6-phosphate dehydrogenase resides in the endoplasmic reticulum lumen and co-local... |
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A missense mutation in the glucosamine-6-phosphate N-acetyltransferase-encoding gene causes temperature-dependent growth defects and ectopic lignin deposition in Arabidopsis.
Plant Cell 24(8) , 3366-79, (2012) To study the regulatory mechanisms underlying lignin biosynthesis, we isolated and characterized lignescens (lig), a previously undescribed temperature-sensitive mutant of Arabidopsis thaliana that exhibits ectopic lignin deposition and growth defects under h... |
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Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme.
Biochemistry 48(15) , 3239-46, (2009) The glmS ribozyme is the first naturally occurring catalytic RNA that relies on an exogenous, nonnucleotide cofactor for reactivity. From a biochemical perspective, the glmS ribozyme derived from Bacillus anthracis is the best characterized. However, much of ... |
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Use of a coenzyme by the glmS ribozyme-riboswitch suggests primordial expansion of RNA chemistry by small molecules.
Philos. Trans. R. Soc. Lond., B, Biol. Sci. 366(1580) , 2942-8, (2011) The glmS ribozyme-riboswitch is the first known example of a naturally occurring catalytic RNA that employs a small molecule as a coenzyme. Binding of glucosamine-6-phosphate (GlcN6P) activates self-cleavage of the bacterial ribozyme, which is part of the mRN... |
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Analysis of metal ion dependence in glmS ribozyme self-cleavage and coenzyme binding.
ChemBioChem. 11(18) , 2567-71, (2010) The bacterial glmS ribozyme is mechanistically unique among both riboswitches and RNA catalysts. Its self-cleavage activity is the basis of riboswitch regulation of glucosamine-6-phosphate (GlcN6P) production, and catalysis requires GlcN6P as a coenzyme. Prev... |
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Rapid steps in the glmS ribozyme catalytic pathway: cation and ligand requirements.
Biochemistry 50(13) , 2424-33, (2011) The glmS ribozyme is a conserved riboswitch found in numerous Gram-positive bacteria and responds to the cellular concentrations of glucosamine 6-phosphate (GlcN6P). GlcN6P binding promotes site-specific self-cleavage in the 5' UTR of the glmS mRNA, resulting... |
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Assay for glucosamine 6-phosphate using a ligand-activated ribozyme with fluorescence resonance energy transfer or CE-laser-induced fluorescence detection.
Anal. Chem. 80(21) , 8195-201, (2008) A naturally occurring aptazyme, the glmS ribozyme, is adapted to an assay for glucosamine 6-phosphate, an effector molecule for the aptazyme. In the assay, binding of analyte allosterically activates aptazyme to cleave a fluorescently labeled oligonucleotide ... |
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N-acetylglucosamine-6-phosphate deacetylase (NagA) of Listeria monocytogenes EGD, an essential enzyme for the metabolism and recycling of amino sugars.
Arch. Microbiol. 194(4) , 255-68, (2012) The main aim of our study was to determine the physiological function of NagA enzyme in the Listeria monocytogenes cell. The primary structure of the murein of L. monocytogenes is very similar to that of Escherichia coli, the main differences being amidation ... |
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Caged glucosamine-6-phosphate for the light-control of riboswitch activity.
Photochem. Photobiol. Sci. 11(3) , 489-92, (2012) We have synthesized a light-activatable ("caged") derivative of glucosamine-6-phosphate (GlcN6P), which only upon irradiation becomes a cofactor for the glmS riboswitch. This glmS riboswitch maintains its activity when embedded in the 3'-untranslated region o... |