丁苯那嗪
丁苯那嗪结构式
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常用名 | 丁苯那嗪 | 英文名 | Tetrabenazine |
|---|---|---|---|---|
| CAS号 | 58-46-8 | 分子量 | 317.423 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 448.9±45.0 °C at 760 mmHg | |
| 分子式 | C19H27NO3 | 熔点 | 128-130ºC | |
| MSDS | 中文版 美版 | 闪点 | 225.3±28.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion.
Psychopharmacol. Ser. 232(7) , 1313-23, (2015) Depressed people show effort-related motivational symptoms, such as anergia, retardation, lassitude, and fatigue. Animal tests can model these motivational symptoms, and the present studies characterized the effort-related effects of the vesicular monoamine t... |
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Effect of NMDAR antagonists in the tetrabenazine test for antidepressants: comparison with the tail suspension test.
Acta Neuropsychiatr. 27 , 228-34, (2015) The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine, produces rapid and enduring antidepressant effect in patients with treatment-resistant depression. Similar dramatic effects have not been observed in clinical trials with other NMDAR antagonists i... |
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"Mixed" anionic and non-ionic micellar liquid chromatography for high-speed radiometabolite analysis of positron emission tomography radioligands.
J. Chromatogr. A. 1281 , 54-9, (2013) A mixed micellar liquid chromatographic (LC) method, the mobile phase consisting of anionic and non-ionic surfactants, has been developed for the high-speed direct radiometabolite analysis of positron emission tomography (PET) radioligands in plasma. The addi... |
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Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression.
J. Neurosci. 33(49) , 19120-30, (2013) Motivated behaviors are often characterized by a high degree of behavioral activation, and work output and organisms frequently make effort-related decisions based upon cost/benefit analyses. Moreover, people with major depression and other disorders often sh... |
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GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine.
J. Neurochem. 127(2) , 177-86, (2013) (R)-3-[2,6-cis-Di(4-methoxyphenethyl)piperidin-1-yl]propane-1,2-diol (GZ-793A) inhibits methamphetamine-evoked dopamine release from striatal slices and methamphetamine self-administration in rats. GZ-793A potently and selectively inhibits dopamine uptake at ... |
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The VMAT-2 inhibitor tetrabenazine affects effort-related decision making in a progressive ratio/chow feeding choice task: reversal with antidepressant drugs.
PLoS ONE 9(6) , e99320, (2014) Behavioral activation is a fundamental feature of motivation, and organisms frequently make effort-related decisions based upon evaluations of reinforcement value and response costs. Furthermore, people with major depression and other disorders often show ane... |
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Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: behavior, positron emission tomography, immunohistochemistry.
Exp. Neurol. 247 , 19-24, (2013) Several independent lines of research suggest that disruption of the ubiquitin proteasome system (UPS) may play a role in the pathophysiology of Parkinson's disease. Direct intracerebral injection of UPS inhibitors (e.g. lactacystin) in animals has consistent... |
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PET quantification of pancreatic VMAT 2 binding using (+) and (-) enantiomers of [¹⁸F]FP-DTBZ in baboons.
Nucl. Med. Biol. 40(1) , 60-4, (2013) The exact cause(s) of apparent overestimation of β cell mass (BCM) with vesicular monoamine transporter type 2 (VMAT2) PET imaging in type 1 diabetes (T1D) is unknown. The objectives were to estimate in baboons non-displaceable binding of [¹⁸F]fluoropropyl (F... |
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Simple, rapid and reliable preparation of [¹¹C]-(+)-α-DTBZ of high quality for routine applications.
Molecules 17(6) , 6697-704, (2012) [¹¹C]-(+)-α-DTBZ has been used as a marker of dopaminergic terminal densities in human striatum and expressed in islet beta cells in the pancreas. We aimed to establish a fully automated and simple procedure for the synthesis of [¹¹C]-(+)-α-DTBZ for routine a... |
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[Medical aspects of the medical treatment in dystonia].
Bull. Acad. Natl. Med. 195(4-5) , 935-50, (2011) Dystonias encompass a wide range of movement disorders characterized mainly by abnormal postures or movements. Because of this semiological and etiological heterogeneity, robust clinical trials are rare. Specific etiological treatments are available for only ... |