四氢叶酸
四氢叶酸结构式
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常用名 | 四氢叶酸 | 英文名 | L-5,6,7,8-Tetrahydrofolic acid |
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| CAS号 | 135-16-0 | 分子量 | 445.42900 | |
| 密度 | 1.7g/cm3 | 沸点 | 555.12°C (rough estimate) | |
| 分子式 | C19H23N7O6 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Quantitation of 5-Methyltetrahydrofolic Acid in Dried Blood Spots and Dried Plasma Spots by Stable Isotope Dilution Assays.
PLoS ONE 10 , e0143639, (2015) Because of minimal data available on folate analysis in dried matrix spots (DMSs), we combined the advantages of stable isotope dilution assays followed by LC-MS/MS analysis with DMS sampling to develop a reliable method for the quantitation of plasma 5-methy... |
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Arg-265: a critical residue of L.donovani cytosolic SHMT in maintaining the binding of THF and catalysis.
Exp. Parasitol. 149 , 16-23, (2015) Serine hydroxymethyltransferase belongs to the class of pyridoxal-5-phosphate enzymes along with aspartate aminotransferase. To explore the function of residue(s) involved in binding of the carboxylate group of Tetrahydrofolic acid (THF) to L. donovani cytoso... |
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Folate levels measured by LC-MS/MS in patients with colorectal cancer treated with different leucovorin dosages.
Cancer Chemother. Pharmacol. 74(6) , 1167-74, (2014) Calcium folinate (leucovorin), which is converted in vivo into biologically active folate, enhances the potency of 5-fluorouracil (5-FU)-based chemotherapy in colorectal cancer. A common dosage of leucovorin in adjuvant and palliative settings is 60 mg/m(2). ... |
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Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate.
Biochem. Biophys. Res. Commun. 449(4) , 392-8, (2014) Dimethylglycine dehydrogenase (DMGDH) is a mammalian mitochondrial enzyme which plays an important role in the utilization of methyl groups derived from choline. DMGDH is a flavin containing enzyme which catalyzes the oxidative demethylation of dimethylglycin... |
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A pharmacokinetic and pharmacodynamic investigation of Modufolin® compared to Isovorin® after single dose intravenous administration to patients with colon cancer: a randomized study.
Cancer Chemother. Pharmacol. 75(1) , 37-47, (2015) Leucovorin is commonly used as folate supplement in 5-fluorouracil-based chemotherapy, but needs to be converted to active 5,10-methylenetetrahydrofolate (methyleneTHF) intracellularly. This provides for interindividual differences. MethyleneTHF has recently ... |
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Novel synthesis of 8-deaza-5,6,7,8-tetrahydroaminopterin analogues via an aziridine intermediate.
Molecules 17(5) , 5604-14, (2012) An efficient method for the construction of the tetrahydrofolate skeleton is described. Starting from pterin analogues and aromatic amines, 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives and the heterocyclic benzoyl isosteres were synthesized via a novel a... |
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The diversity-oriented synthesis of pteridines - achievements and potential for development.
IUBMB Life 65(4) , 283-99, (2013) The importance of pteridines in the key cofactors, tetrahydrofolate and tetrahydrobiopterin, has encouraged the development of the chemistry and chemical biology of pteridines. In order to investigate the latter, versatile synthetic methods are required to pr... |
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Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1.
Protein Sci. 20(8) , 1398-410, (2011) Thymidylate synthase X (ThyX) catalyzes the methylation of dUMP to form dTMP in bacterial life cycle and is regarded as a promising target for antibiotics discovery. Helicobacter pylori is a human pathogen associated with a number of human diseases. Here, we ... |
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Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum.
Biochem. Biophys. Res. Commun. 406(3) , 459-63, (2011) Folate co-enzymes play a pivotal role in one-carbon transfer cellular processes. Many eukaryotes encode the tri-functional tetrahydrofolate dehydrogenase/cyclohydrolase/synthetase (deh/cyc/syn) enzyme, which consists of a N-terminal bifunctional domain (deh/c... |
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Reversible corneal epitheliopathy caused by vitamin B12 and folate deficiency in a vegan with a genetic mutation: a new disease.
Eye (Lond.) 25(11) , 1512-4, (2011)
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