维替泊芬
维替泊芬结构式
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常用名 | 维替泊芬 | 英文名 | Verteporfin |
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| CAS号 | 129497-78-5 | 分子量 | 718.79 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C41H42N4O8 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Verteporfin therapy and triamcinolone acetonide: convergent modes of action for treatment of neovascular age-related macular degeneration.
Eur. J. Ophthalmol. 16(6) , 824-34, (2006) Choroidal neovascularization associated with age-related macular degeneration is the primary cause of blindness in the elderly in developed countries, due to a number of pathogenic effects, including angiogenesis, cell-mediated inflammation, leukocyte adhesio... |
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NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition.
Cancer Discov. 5 , 1178-93, (2015) Ch22q LOH is preferentially associated with RAS mutations in papillary and in poorly differentiated thyroid cancer (PDTC). The 22q tumor suppressor NF2, encoding merlin, is implicated in this interaction because of its frequent loss of function in human thyro... |
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Aerobic glycolysis tunes YAP/TAZ transcriptional activity.
EMBO J. 34 , 1349-70, (2015) Increased glucose metabolism and reprogramming toward aerobic glycolysis are a hallmark of cancer cells, meeting their metabolic needs for sustained cell proliferation. Metabolic reprogramming is usually considered as a downstream consequence of tumor develop... |
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Liposomal hypocrellin B as a potential photosensitizer for age-related macular degeneration: pharmacokinetics, photodynamic efficacy, and skin phototoxicity in vivo.
Photochem. Photobiol. Sci. 14 , 972-81, (2015) Photodynamic therapy (PDT) has been successfully implemented as a treatment for wet age-related macular degeneration (AMD), but very few photosensitizers have been developed for clinical use. Herein, we describe a novel formulation of liposomal hypocrellin B ... |
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Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.
J. Exp. Med. 211(11) , 2249-63, (2014) Genetic studies have shown that the tuberous sclerosis complex (TSC) 1-TSC2-mammalian target of Rapamycin (mTOR) and the Hippo-Yes-associated protein 1 (YAP) pathways are master regulators of organ size, which are often involved in tumorigenesis. The crosstal... |
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The effect of photodynamic therapy on cisterna chyli patency in rats.
Vet. Surg. 43(6) , 642-9, (2014) To radiographically and histologically evaluate the effects of photodynamic therapy on the cisterna chyli in rats.Experimental study.Adult male Sprague-Dawley rats (n = 60).Cecal lymph nodes were injected with the photodynamic compound verteporfin. A 690 nm, ... |
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The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation.
Exp. Eye Res. 124 , 67-73, (2014) Verteporfin (VP), a benzoporphyrin derivative, is clinically used in photodynamic therapy for neovascular macular degeneration. Recent studies indicate that VP may inhibit growth of hepatoma cells without photoactivation through inhibition of YAP-TEAD complex... |
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Half-fluence versus half-dose photodynamic therapy in chronic central serous chorioretinopathy.
Am. J. Ophthalmol. 157(5) , 1033-7, (2014) To compare the efficacy and safety of half-fluence vs half-dose photodynamic therapy (PDT) in chronic central serous chorioretinopathy (CSC).Multicenter retrospective comparison study.Retrospective review of 56 patients affected by chronic CSC, including 28 p... |
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Efficacy of half-fluence photodynamic therapy depending on the degree of choroidal hyperpermeability in chronic central serous chorioretinopathy.
Eye (Lond.) 27(3) , 353-62, (2013) The purpose of this study is to determine the efficacy of half-fluence photodynamic therapy (PDT) depending on the degree of hyperfluorescence based on indocyanine green angiography (ICGA) for treatment of chronic central serous chorioretinopathy (CSC).We con... |
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Assessment of choroidal topographic changes by swept source optical coherence tomography after photodynamic therapy for central serous chorioretinopathy.
Am. J. Ophthalmol. 157(4) , 852-60, (2014) To investigate the relationship between choroidal thickness and angiographic abnormalities in central serous chorioretinopathy (CSC) eyes by swept-source optical coherence tomography (swept-OCT), before and after half-fluence photodynamic therapy (PDT).Prospe... |