盐酸妥布特罗
盐酸妥布特罗结构式
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常用名 | 盐酸妥布特罗 | 英文名 | Tulobuterol hydrochloride |
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| CAS号 | 56776-01-3 | 分子量 | 264.191 | |
| 密度 | 1.098 g/cm3 | 沸点 | 338.2ºC at 760 mmHg | |
| 分子式 | C12H19Cl2NO | 熔点 | 163ºC | |
| MSDS | 中文版 美版 | 闪点 | 158.3ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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[Clinical effects of budesonide/formoterol combination drug in elder patients with asthma compared with budesonide plus tulobuterol patch combination treatment].
Arerugi. 61(6) , 820-31, (2012) Tulobuterol patch (Tulo) is often used for treatment of elder patient with asthma in Japan. However, there is no evidence either ICS plus Tulo or ICS/LABA combination is better for elder patient.Elder patients with asthma (aged≥ 70, n=17) who had treated with... |
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Effects of the tulobuterol patch on the treatment of acute asthma exacerbations in young children.
Allergy Asthma Proc. 33(3) , e28-34, (2012) The tulobuterol patch (TP) is a beta(2)-adrenergic agonist with a favorable pharmacokinetic profile used for asthma management in Japan. Because it contains tulobuterol in a molecular, crystallized form that is gradually absorbed percutaneously, TP exerts a p... |
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Effects of transdermal tulobuterol in pediatric asthma patients on long-term leukotriene receptor antagonist therapy: results of a randomized, open-label, multicenter clinical trial in Japanese children aged 4-12 years.
Allergol. Int. 62(1) , 37-43, (2013) Few studies have examined the efficacy or safety of a transdermal β(2) agonist as add-on medication to long-term leukotriene receptor antagonist (LTRA) therapy in pediatric asthma patients.In this randomized, open-label, multicenter clinical trial, children a... |
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[Questionnaire survey on the change of asthmatic response, adverse events and product usability due to drug switching between name-brand and generic tulobuterol tapes].
Yakugaku Zasshi 132(5) , 617-27, (2012) Aggravation of asthmatic response (asthmatic attack, 2 cases) and adverse events (tremor, 1 case) due to a switch from a brand-name tulobuterol tape to a generic tape were recently reported. These changes disappeared after reformulation from generic to the br... |
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β2-adrenergic receptor haplotype may be associated with susceptibility to desensitization to long-acting β2-agonists in COPD patients.
Lung 190(4) , 411-7, (2012) Τhat β2-adrenergic receptor (β2AR) haplotypes may play a key role in clinical response to β2-agonists and haplotype Cys-19Gly16Gln27 (CysGlyGln) is reported to be associated with desensitization of β2AR to β-agonists in lymphocytes isolated from patients with... |
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Study of the physicochemical properties of tulobuterol dry syrups using taste and smell sensors.
Chem. Pharm. Bull. 60(4) , 442-8, (2012) The purpose of the present study was to evaluate the taste and smell of Tulobuterol Dry Syrup (TB-DS) in its original form (formulation A) and generic form (formulations B and C) by means of gustatory sensation tests and taste and smell sensors. In addition, ... |
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Influence of 1-D silica nanotubes as drug adsorbent on release behaviors of tulobuterol-loaded porous microcapsules.
Colloids Surf. B Biointerfaces 92 , 240-5, (2012) Porous poly(ε-caprolactone) (PCL)/Eudragit RS 100 (ERS-100) microcapsules containing tulobuterol-adsorbed silica nanotubes (S-NTs) were prepared using a solvent evaporation method. The release behaviors of the PCL/ERS-100 microcapsules were investigated as a ... |
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Evaluation of the predicted time-concentration profile of serum tulobuterol in human after transdermal application.
Chem. Pharm. Bull. 60(3) , 300-5, (2012) We proposed an in vitro/in vivo/in silico method for evaluating the clinical performance of matrix type transdermal therapeutic systems (TTSs). This method is based on the following four approaches: (1) drug release experiment, (2) in vitro penetration experi... |
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Clinical efficacy of the transdermal tulobuterol patch in patients with chronic obstructive pulmonary disease: a comparison with slow-release theophylline.
Intern. Med. 47(6) , 503-9, (2008) There is insufficient evidence for the efficacy of a transdermal tulobuterol patch (TP), although combination therapy with bronchodilators is recommended for chronic obstructive pulmonary disease (COPD).A randomized, controlled crossover study was conducted t... |