甘氨酸-脯氨酸-精氨酸-脯氨酸
甘氨酸-脯氨酸-精氨酸-脯氨酸结构式
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常用名 | 甘氨酸-脯氨酸-精氨酸-脯氨酸 | 英文名 | GPRP |
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| CAS号 | 67869-62-9 | 分子量 | 425.48300 | |
| 密度 | 1.55 g/cm3 | 沸点 | N/A | |
| 分子式 | C18H31N7O5 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi.
J. Thromb. Haemost. 12(8) , 1342-52, (2014) Integrin-linked kinase (ILK) and its associated complex of proteins are involved in many cellular activation processes, including cell adhesion and integrin signaling. We have previously demonstrated that mice with induced platelet ILK deficiency show reduced... |
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Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP.
Blood 126 , 873-9, (2015) Immune thrombocytopenia (ITP) patients with similarly low platelet counts differ in their tendency to bleed. To determine if differences in platelet function in ITP patients account for this variation in bleeding tendency, we conducted a single-center, cross-... |
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Procoagulant platelets form an α-granule protein-covered "cap" on their surface that promotes their attachment to aggregates.
J. Biol. Chem. 288(41) , 29621-32, (2013) Strongly activated "coated" platelets are characterized by increased phosphatidylserine (PS) surface expression, α-granule protein retention, and lack of active integrin αIIbβ3. To study how they are incorporated into thrombi despite a lack of free activated ... |
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Fibrinogen residue γAla341 is necessary for calcium binding and 'A-a' interactions.
Thromb. Haemost. 107(5) , 875-83, (2012) The fibrinogen γ-module has several important sites relating to fibrinogen function, which include the high affinity calcium binding site, hole 'a' that binds with knob 'A', and the D:D interface. Residue γAla341, which is located in the vicinity of these sit... |
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Role of 'B-b' knob-hole interactions in fibrin binding to adsorbed fibrinogen.
J. Thromb. Haemost. 5(12) , 2344-51, (2007) The formation of a fibrin clot is supported by multiple interactions, including those between polymerization knobs 'A' and 'B' exposed by thrombin cleavage and polymerization holes 'a' and 'b' present in fibrinogen and fibrin. Although structural studies have... |
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B:b interactions are essential for polymerization of variant fibrinogens with impaired holes 'a'.
J. Thromb. Haemost. 5(12) , 2352-9, (2007) Fibrin polymerization is mediated by interactions between knobs 'A' and 'B' exposed by thrombin cleavage, and holes 'a' and 'b' always present in fibrinogen. The role of A:a interactions is well established, but the roles of knob:hole interactions A:b, B:b or... |
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Which knobs fit into which holes in fibrin polymerization?
J. Thromb. Haemost. 5(12) , 2340-3, (2007)
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The synthetic peptide Gly-Pro-Arg-Pro-amide limits the plasmic digestion of fibrinogen in the same fashion as calcium ion.
Protein Sci. 1(12) , 1719-20, (1992)
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The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro.
Proc. Natl. Acad. Sci. U. S. A. 94(14) , 7176-81, (1997) After vascular injury, a cascade of serine protease activations leads to the conversion of the soluble fibrinogen molecule into fibrin. The fibrin monomers then polymerize spontaneously and noncovalently to form a fibrin gel. The primary interaction of this p... |
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Binding of thrombin-activated platelets to a fibrin scaffold through α(IIb)β₃ evokes phosphatidylserine exposure on their cell surface.
PLoS ONE 8(2) , e55466, (2013) Recently, by employing intra-vital confocal microscopy, we demonstrated that platelets expose phosphatidylserine (PS) and fibrin accumulate only in the center of the thrombus but not in its periphery. To address the question how exposure of platelet anionic p... |