Selisistat
Selisistat结构式
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常用名 | Selisistat | 英文名 | Selisistat (EX 527) |
|---|---|---|---|---|
| CAS号 | 49843-98-3 | 分子量 | 248.708 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 531.7±38.0 °C at 760 mmHg | |
| 分子式 | C13H13ClN2O | 熔点 | 179.0 to 183.0 °C | |
| MSDS | 中文版 美版 | 闪点 | 275.4±26.8 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression.
Cell Death Dis. 6 , e1827, (2015) Disturbed cell autophagy is found in various cardiovascular disease conditions. Biomechanical stimuli induced by laminar blood flow have important protective actions against the development of various vascular diseases. However, the impacts and underlying mec... |
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Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro.
Int. J. Mol. Med. 37 , 83-91, (2015) Radiocontrast-induced nephropathy (RIN) is one of the leading causes of hospital-acquired acute kidney injury (AKI). The clinical strategies currently available for the prevention of RIN are insufficient. In this study, we aimed to determine whether resveratr... |
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Immunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected Erythrocytes.
Stem Cells Dev. 23(20) , 2435-42, (2014) Adhesion of Plasmodium falciparum-infected red blood cells (iRBC) to human erythrocytes (i.e. rosetting) is associated with severe malaria. Rosetting results from interactions between a subset of variant PfEMP1 (Plasmodium falciparum erythrocyte membrane prot... |
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Preferential expression of PAPPA in human preadipocytes from omental fat.
J. Endocrinol. 222(1) , 87-97, (2014) Fat distribution differs between individuals, and those with visceral fat predominance develop metabolic profiles that increase the risk of adverse cardiovascular events. This is due, in part, to the proinflammatory state associated with visceral obesity as w... |
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A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer.
J. Biol. Chem. 289(8) , 5208-16, (2014) Sirtuin 2 (SIRT2) is an NAD(+)-dependent protein deacetylase whose targets include histone H4 lysine 16, p53, and α-tubulin. Because deacetylation of p53 regulates its effect on apoptosis, pharmacological inhibition of SIRT2-dependent p53 deacetylation is of ... |
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Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses.
J. Immunol. 195 , 1637-46, (2015) Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in children worldwide. Sirtuin 1 (SIRT1), an NAD(+)-dependent deacetylase, has been associated with the induction of autophagy and the regulation of inflammatory mediato... |
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The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice.
Endocrinology 155(9) , 3508-15, (2014) Estrogen deficiency leads to rapid bone loss and skeletal fragility. Sclerostin, encoded by the sost gene, and a product of the osteocyte, is a negative regulator of bone formation. Blocking sclerostin increases bone mass and strength in animals and humans. S... |
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Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL).
Cancer Biol. Ther. 17 , 300-9, (2016) Sirtuins (SIRT) are nicotinamide adenine dinucleotide (NAD+) dependent deacetylases or ADP- ribosyl transferases (ARTs) that deacetylate lysine residues on various proteins regulating a variety of cellular and metabolic processes. These enzymes regulate metab... |
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Adversity in childhood and depression: linked through SIRT1.
Transl. Psychiatry 5 , e629, (2015) Experiencing an adverse childhood and parental neglect is a risk factor for depression in the adult population. Patients with a history of traumatic childhood develop a subtype of depression that is characterized by earlier onset, poor treatment response and ... |