盐酸奥洛他定
盐酸奥洛他定结构式
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常用名 | 盐酸奥洛他定 | 英文名 | Olopatadine Hydrochloride |
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| CAS号 | 140462-76-6 | 分子量 | 373.873 | |
| 密度 | 1.221 g/cm3 | 沸点 | 523ºC at 760mmHg | |
| 分子式 | C21H24ClNO3 | 熔点 | 242-245ºC | |
| MSDS | 中文版 美版 | 闪点 | 270.1ºC | |
| 符号 |
GHS06, GHS09 |
信号词 | Danger |
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Topical cyclosporine a 1% for the treatment of chronic ocular surface inflammation.
Eye Contact Lens 40(5) , 283-8, (2014) To evaluate the use of topical cyclosporine A (CsA) 1% emulsion in the treatment of chronic ocular surface inflammation (OSI).We conducted a retrospective chart review of patients with various forms of OSI treated with topical CsA 1% from 2001 to 2012.Twenty-... |
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Histamine suppresses regulatory T cells mediated by TGF-β in murine chronic allergic contact dermatitis.
Exp. Dermatol. 24(4) , 280-4, (2015) Regulatory T cells (Tregs) suppress effector T cells and ameliorate contact hypersensitivity (CH); however, the role of Tregs in chronic allergic contact dermatitis (CACD) has not been assessed. Repeated elicitation of CH has been used to produce CACD models ... |
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Chromatographic analysis of olopatadine in hydrophilic interaction liquid chromatography.
J. Chromatogr. Sci. 53 , 680-6, (2015) In this paper, chromatographic analysis of active substance olopatadine hydrochloride, which is used in eye drops as antihistaminic agent, and its impurity E isomer by hydrophilic interaction liquid chromatography (HILIC) and application of design of experime... |
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Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors.
Biochem. Pharmacol. 91(2) , 231-41, (2014) Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and sec... |
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Development and validation of an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistaminics in dietary supplements.
Biomed. Chromatogr. 29(3) , 465-74, (2015) The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged fr... |
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Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria.
J. Allergy Clin. Immunol. 134(3) , 622-633.e9, (2014) Wheal reactions to intradermally injected neuropeptides, such as substance P (SP) and vasoactive intestinal peptide, are significantly larger and longer lasting in patients with chronic urticaria (CU) than in nonatopic control (NC) subjects. Mas-related gene ... |
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The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats.
Biol. Pharm. Bull. 35(5) , 693-7, (2012) Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy. The purpose of this study was to investigate whether olopatadine, one of the most e... |
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Efficacy of epinastine hydrochloride ophthalmic solution in allergic conjunctivitis by conjunctival cedar pollen allergen challenge.
Ann. Allergy Asthma Immunol. 113(4) , 476-81, (2014) Epinastine hydrochloride is a selective histamine H1 receptor antagonist that also inhibits IgE receptor-mediated histamine release from mast cells.To show the superiority of epinastine 0.05% ophthalmic solution (epinastine) to placebo ophthalmic solution (pl... |
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[Pharmacological profile and clinical efficacy of olopatadine hydrochloride ophthalmic solution (Patanol 0.1% ophthalmic solution)].
Nippon. Yakurigaku Zasshi. 130(3) , 221-31, (2007)
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Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug.
Jpn. J. Pharmacol. 88(4) , 379-97, (2002) Olopatadine hydrochloride (olopatadine, 11-[(Z)-3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride) is a novel antiallergic/histamine H1-receptor antagonistic drug that was synthesized and evaluated in our laboratories... |