NKY80
NKY80结构式
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常用名 | NKY80 | 英文名 | NKY 80 |
|---|---|---|---|---|
| CAS号 | 299442-43-6 | 分子量 | 229.23500 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C12H11N3O2 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | N/A | |
| 符号 |
GHS06 |
信号词 | Danger |
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Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.
Cardiovasc. Res. 107 , 184-96, (2015) Enhanced cardiac late Na current (late INa) and increased sarcoplasmic reticulum (SR)-Ca(2+)-leak are both highly arrhythmogenic. This study seeks to identify signalling pathways interconnecting late INa and SR-Ca(2+)-leak in atrial cardiomyocytes (CMs).In mu... |
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In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Proc. Natl. Acad. Sci. U. S. A. 105 , 9059-64, (2008) The growing resistance to current first-line antimalarial drugs represents a major health challenge. To facilitate the discovery of new antimalarials, we have implemented an efficient and robust high-throughput cell-based screen (1,536-well format) based on p... |
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Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
Science 334 , 1372-7, (2011) Most malaria drug development focuses on parasite stages detected in red blood cells, even though, to achieve eradication, next-generation drugs active against both erythrocytic and exo-erythrocytic forms would be preferable. We applied a multifactorial appro... |