芬维A胺
芬维A胺结构式
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常用名 | 芬维A胺 | 英文名 | Fenretinide |
|---|---|---|---|---|
| CAS号 | 65646-68-6 | 分子量 | 391.546 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 597.6±42.0 °C at 760 mmHg | |
| 分子式 | C26H33NO2 | 熔点 | 162-163°C | |
| MSDS | 中文版 美版 | 闪点 | 315.2±27.9 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
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Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes.
PLoS ONE 10(2) , e0115686, (2015) Antimetabolites are a class of effective anticancer drugs interfering in essential biochemical processes. 5-Fluorouracil (5-FU) and its prodrug Capecitabine are widely used in the treatment of several solid tumors (gastro-intestinal, gynecological, head and n... |
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Enhanced killing of SCC17B human head and neck squamous cell carcinoma cells after photodynamic therapy plus fenretinide via the de novo sphingolipid biosynthesis pathway and apoptosis.
Int. J. Oncol. 46(5) , 2003-10, (2015) Because photodynamic therapy (PDT) alone is not always effective as an anticancer treatment, PDT is combined with other anticancer agents for improved efficacy. The clinically-relevant fenretinide [N-(4-hydroxyphenyl) retinamide; 4HPR], was combined with the ... |
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Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics.
Biochim. Biophys. Acta 1851 , 919-28, (2015) The triphenylethylene antiestrogen, tamoxifen, can be an effective inhibitor of sphingolipid metabolism. This off-target activity makes tamoxifen an interesting ancillary for boosting the apoptosis-inducing properties of ceramide, a sphingolipid with valuable... |
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Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.
Mol. Cancer 14(1) , 204, (2015) An inverse correlation between expression of the aldehyde dehydrogenase 1 subfamily A2 (ALDH1A2) and gene promoter methylation has been identified as a common feature of oropharyngeal squamous cell carcinoma (OPSCC). Moreover, low ALDH1A2 expression was assoc... |
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Fenretinide prevents inflammation and airway hyperresponsiveness in a mouse model of allergic asthma.
Am. J. Respir. Cell. Mol. Biol. 51(6) , 783-92, (2014) Arachidonic acid (AA) and docosahexaenoic acid (DHA) play important roles in inflammation and disease progression, where AA is viewed as proinflammatory and DHA as antiinflammatory. We observe in our model of allergic asthma that the AA/DHA ratio is significa... |
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Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C.
BMC Cancer 12 , 147, (2012) Our recent study showed that tetrathiomolybdate (TM), a drug to treat copper overload disorders, can sensitize drug-resistant endometrial cancer cells to reactive oxygen species (ROS)-generating anticancer drug doxorubicin. To expand these findings in the pre... |
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Mcl-1 is an important therapeutic target for oral squamous cell carcinomas.
Oncotarget 6 , 16623-37, (2015) Oral and oropharyngeal cancers are the sixth most common cancers worldwide. Despite intensive investigation, oral squamous cell carcinomas (OSCC) represent a clinical challenge resulting in significant morbidity and mortality. Resistance to cell death is comm... |
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Fenretinide: a novel treatment for endometrial cancer.
PLoS ONE 9(10) , e110410, (2014) Resistance to progestin treatment is a major hurdle in the treatment of advanced and reoccurring endometrial cancer. Fenretinide is a synthetic retinoid that has been evaluated in clinical trials as a cancer therapeutic and chemo-preventive agent. Fenretinide... |
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The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication.
Antimicrob. Agents Chemother. 59(1) , 85-95, (2014) Dengue virus (DENV), a member of the Flaviviridae family, is a mosquito-borne pathogen and the cause of dengue fever. The increasing prevalence of DENV worldwide heightens the need for an effective vaccine and specific antivirals. Due to the dependence of DEN... |
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Cell-type variation in stress responses as a consequence of manipulating GRP78 expression in neuroectodermal cells.
J. Cell. Biochem. 116(3) , 438-49, (2015) Glucose-regulated protein 78 (GRP78) is a stress sensor which interacts with unfolded protein response (UPR) activators in the endoplasmic reticulum (ER). The aim of this study was to test the hypothesis that GRP78 has distinct functional roles in mediating t... |