单响尾蛇毒蛋白
单响尾蛇毒蛋白结构式
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常用名 | 单响尾蛇毒蛋白 | 英文名 | Crotaline |
|---|---|---|---|---|
| CAS号 | 315-22-0 | 分子量 | 325.357 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 537.3±50.0 °C at 760 mmHg | |
| 分子式 | C16H23NO6 | 熔点 | 204ºC (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 278.7±30.1 °C | |
| 符号 |
GHS06, GHS08 |
信号词 | Danger |
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The Japanese toxicogenomics project: application of toxicogenomics.
Mol. Nutr. Food. Res. 54 , 218-27, (2010) Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety proble... |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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UPLC-MS/MS method for determination of selected pyrrolizidine alkaloids in feed.
Food Chem. 170 , 265-70, (2014) Alkaloids known as secondary metabolites are grouped by typical structural characteristics into large families such as pyrrolizidine alkaloids (PAs) comprising more than 350 individual heterocyclic compounds. The PAs present a serious health risk to human and... |
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Ethyl pyruvate ameliorates monocrotaline-induced pulmonary arterial hypertension in rats.
J. Cardiovasc. Pharmacol. 64(1) , 7-15, (2014) Ethyl pyruvate (EP) is an anti-inflammatory and anti-oxidant agent associated with many diseases. In this study, we evaluated whether EP could attenuate monocrotaline-induced pulmonary arterial hypertension (PAH).A PAH model was established by subcutaneously ... |
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Metabolic activation of pyrrolizidine alkaloids: insights into the structural and enzymatic basis.
Chem. Res. Toxicol. 27(6) , 1030-9, (2014) Pyrrolizidine alkaloids (PAs) are natural toxins widely distributed in plants. The toxic potencies of different PAs vary significantly. PAs are mono- or diesters of necine acids with a necine base. On the basis of the necine bases, PAs are classified into thr... |
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New aspect of plant-rhizobia interaction: alkaloid biosynthesis in Crotalaria depends on nodulation.
Proc. Natl. Acad. Sci. U. S. A. 112(13) , 4164-9, (2015) Infection of legume hosts by rhizobial bacteria results in the formation of a specialized organ, the nodule, in which atmospheric nitrogen is reduced to ammonia. Nodulation requires the reprogramming of the plant cell, allowing the microsymbiont to enter the ... |
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Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension.
Arterioscler. Thromb. Vasc. Biol. 34(7) , 1446-58, (2014) Pulmonary vascular remodeling, the pathological hallmark of pulmonary arterial hypertension, is attributed to proliferation, apoptosis resistance, and migration of vascular cells. A role of dysregulated matrix cross-linking and stability as a pathogenic mecha... |
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Ellagic acid prevents monocrotaline-induced pulmonary artery hypertension via inhibiting NLRP3 inflammasome activation in rats.
Int. J. Cardiol. 180 , 134-41, (2014) Pulmonary artery hypertension (PAH) is characterized by vascular remodeling, high pulmonary blood pressure, and right ventricular hypertrophy. Oxidative stress, inflammation and pulmonary artery remodeling are important components in PAH. Ellagic acid (EA) is... |
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Cervical ganglion block attenuates the progression of pulmonary hypertension via nitric oxide and arginase pathways.
Hypertension 63(2) , 309-15, (2014) It has been recognized that the sympathetic nervous system is activated in pulmonary arterial hypertension (PAH), and abnormal sympathetic hyperactivity leads to worsening of PAH via endothelial dysfunction. The purpose of this study was to examine whether sy... |